BAIT
SFN
Er, Mme1, Ywhas, RP23-137L22.11-001
stratifin
GO Process (15)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- establishment of skin barrier [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- keratinization [IMP]
- keratinocyte development [IGI]
- keratinocyte differentiation [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of keratinocyte proliferation [IGI]
- positive regulation of cell growth [IDA]
- positive regulation of epidermal cell differentiation [IMP]
- positive regulation of protein export from nucleus [IDA]
- regulation of cell cycle [IDA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- regulation of epidermal cell division [IMP]
- release of cytochrome c from mitochondria [ISO]
- skin development [IGI, IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
APLP2
AI790698, APLP-2
amyloid beta (A4) precursor-like protein 2
GO Process (12)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- cellular copper ion homeostasis [IMP]
- cholesterol metabolic process [IGI]
- embryo development [IGI]
- extracellular matrix organization [IGI]
- forebrain development [IGI]
- locomotory behavior [IGI]
- mating behavior [IGI]
- midbrain development [IGI]
- neuromuscular process controlling balance [IGI]
- regulation of epidermal growth factor-activated receptor activity [IGI]
- regulation of protein binding [IGI]
- suckling behavior [IGI]
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.827 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID