BAIT
CTTN
1110020L01Rik, Ems1
cortactin
GO Process (12)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- cell motility [ISO]
- dendritic spine maintenance [IGI]
- focal adhesion assembly [ISO]
- intracellular protein transport [ISO]
- lamellipodium organization [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IGI]
- neuron projection morphogenesis [ISO]
- positive regulation of actin filament polymerization [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of axon extension [ISO]
- substrate-dependent cell migration, cell extension [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin filament [ISO]
- cell cortex [IDA]
- cell junction [ISO]
- coated pit [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- lamellipodium [IDA, ISO]
- mitotic spindle midzone [IDA]
- ruffle [IDA]
- voltage-gated potassium channel complex [ISO]
Mus musculus
PREY
ATG7
1810013K23Rik, Agp7, Apg7l, Atg7l, Gm21553
autophagy related 7
GO Process (37)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- adult walking behavior [IMP]
- autophagy [IMP]
- cardiac muscle cell development [IMP]
- cellular amino acid metabolic process [IMP]
- cellular response to hyperoxia [ISO]
- cellular response to nitrogen starvation [IBA]
- cellular response to starvation [ISO]
- central nervous system neuron axonogenesis [IMP]
- cerebellar Purkinje cell layer development [IMP]
- cerebral cortex development [IMP]
- late nucleophagy [IBA]
- liver development [IMP]
- macroautophagy [IBA]
- membrane organization [IMP]
- mitochondrion degradation [IBA]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of histone H4-K16 acetylation [IMP]
- negative stranded viral RNA replication [IMP]
- neurological system process [IMP]
- neuron projection development [IMP]
- organelle organization [IMP]
- piecemeal microautophagy of nucleus [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of autophagy [ISO]
- positive regulation of macroautophagy [ISO]
- positive regulation of mucus secretion [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein modification process [IDA, ISO]
- post-embryonic development [IMP]
- protein catabolic process [IMP]
- protein lipidation [ISO]
- protein modification by small protein conjugation [IMP]
- pyramidal neuron development [IMP]
- regulation of protein ubiquitination [IMP]
- response to starvation [IMP]
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.718 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID