BAIT
HSPD1
60kDa, Hsp60
heat shock protein 1 (chaperonin)
GO Process (24)
GO Function (11)
GO Component (23)
Gene Ontology Biological Process
- B cell activation [ISO]
- B cell cytokine production [ISO]
- B cell proliferation [ISO]
- MyD88-dependent toll-like receptor signaling pathway [ISO]
- T cell activation [IDA, IGI, ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- chaperone mediated protein folding requiring cofactor [ISO]
- detection of misfolded protein [ISO]
- isotype switching to IgG isotypes [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of T cell activation [IDA, ISO]
- positive regulation of T cell mediated immune response to tumor cell [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-alpha production [IDA, ISO]
- positive regulation of interferon-gamma production [IDA, IGI, ISO]
- positive regulation of interleukin-10 production [ISO]
- positive regulation of interleukin-12 production [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of macrophage activation [ISO]
- protein refolding [ISO]
- protein stabilization [ISO]
- response to unfolded protein [ISO]
Gene Ontology Molecular Function- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [ISO]
- lipopolysaccharide binding [IDA, ISO]
- misfolded protein binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [ISO]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [ISO]
- lipopolysaccharide binding [IDA, ISO]
- misfolded protein binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [ISO]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell surface [ISO]
- coated pit [ISO]
- coated vesicle [ISO]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [IDA]
- lipopolysaccharide receptor complex [ISO]
- membrane [ISO]
- membrane raft [ISO]
- mitochondrial crista [ISO]
- mitochondrial inner membrane [IDA]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- plasma membrane [IDA]
- protein complex [ISO]
- rough endoplasmic reticulum [ISO]
- secretory granule [IDA, ISO]
- zymogen granule [ISO]
Mus musculus
PREY
CASP3
A830040C14Rik, AC-3, Apopain, CASP-3, CC3, CPP-32, CPP32, Caspase-3, Lice, SCA-1, Yama, mldy
caspase 3
GO Process (35)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- T cell homeostasis [IMP]
- apoptotic process [IDA, ISO]
- cell fate commitment [IMP]
- cellular response to DNA damage stimulus [IDA]
- cellular response to organic substance [IDA]
- erythrocyte differentiation [IBA, ISO]
- execution phase of apoptosis [IDA, IGI, IMP, ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- glial cell apoptotic process [IMP]
- heart development [IGI]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IDA]
- keratinocyte differentiation [IMP]
- learning or memory [ISO]
- negative regulation of B cell proliferation [IMP]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]
- neuron apoptotic process [IDA, IGI, IMP]
- neuron differentiation [IBA]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of neuron apoptotic process [IDA, ISO]
- protein processing [IDA]
- proteolysis [IMP, ISO]
- regulation of apoptotic DNA fragmentation [IMP]
- release of cytochrome c from mitochondria [IGI]
- response to UV [IDA, IGI]
- response to glucose [ISO]
- response to hydrogen peroxide [ISO]
- response to wounding [IDA]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function- aspartic-type endopeptidase activity [IDA, ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IMP]
- cysteine-type endopeptidase activity [IDA, ISO]
- cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- cysteine-type endopeptidase activity involved in execution phase of apoptosis [IDA, ISO]
- cysteine-type peptidase activity [IDA, ISO]
- death receptor binding [ISO]
- peptidase activity [IDA, IMP, ISO]
- phospholipase A2 activator activity [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- aspartic-type endopeptidase activity [IDA, ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IMP]
- cysteine-type endopeptidase activity [IDA, ISO]
- cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- cysteine-type endopeptidase activity involved in execution phase of apoptosis [IDA, ISO]
- cysteine-type peptidase activity [IDA, ISO]
- death receptor binding [ISO]
- peptidase activity [IDA, IMP, ISO]
- phospholipase A2 activator activity [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.724 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID