BAIT
PRMT5
Jbp1, Skb1
protein arginine N-methyltransferase 5
GO Process (14)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- circadian regulation of gene expression [IMP]
- endothelial cell activation [ISO]
- histone H4-R3 methylation [IMP]
- histone arginine methylation [IBA]
- negative regulation of cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- peptidyl-arginine N-methylation [ISO]
- peptidyl-arginine methylation [ISO]
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine [IBA, ISO]
- positive regulation of oligodendrocyte differentiation [ISO]
- protein methylation [ISO]
- regulation of DNA methylation [ISO]
- regulation of ERK1 and ERK2 cascade [ISO]
- spliceosomal snRNP assembly [ISO]
Gene Ontology Molecular Function- chromatin binding [IMP]
- core promoter sequence-specific DNA binding [IDA]
- histone-arginine N-methyltransferase activity [IBA]
- methyltransferase activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein-arginine omega-N symmetric methyltransferase activity [ISO]
- ribonucleoprotein complex binding [ISO]
- transcription corepressor activity [IMP]
- chromatin binding [IMP]
- core promoter sequence-specific DNA binding [IDA]
- histone-arginine N-methyltransferase activity [IBA]
- methyltransferase activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein-arginine omega-N symmetric methyltransferase activity [ISO]
- ribonucleoprotein complex binding [ISO]
- transcription corepressor activity [IMP]
Mus musculus
PREY
CCAR2
2610301G19Rik, mKIAA1967
cell cycle activator and apoptosis regulator 2
GO Process (11)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- RNA splicing [ISO]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- negative regulation of catalytic activity [IDA, ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of DNA damage checkpoint [ISO]
- positive regulation of apoptotic process [ISO]
- regulation of DNA-templated transcription, elongation [ISO]
- regulation of circadian rhythm [IMP]
- regulation of protein stability [ISO]
- response to UV [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.832 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID