BAIT
ATP1A2
AW060654, Atpa-3, mKIAA0778
ATPase, Na+/K+ transporting, alpha 2 polypeptide
GO Process (30)
GO Function (6)
GO Component (15)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- ATP hydrolysis coupled proton transport [ISO]
- adult locomotory behavior [IMP]
- cellular potassium ion homeostasis [ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to steroid hormone stimulus [IDA, ISO]
- cellular sodium ion homeostasis [ISO]
- locomotion [IMP]
- negative regulation of calcium ion transmembrane transport [ISO]
- negative regulation of calcium:sodium antiporter activity [ISO]
- negative regulation of cytosolic calcium ion concentration [IMP]
- negative regulation of heart contraction [IMP]
- negative regulation of striated muscle contraction [IMP]
- neurotransmitter uptake [IMP]
- potassium ion import [ISO]
- potassium ion transport [ISO]
- regulation of blood pressure [IGI]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of muscle contraction [IMP]
- regulation of respiratory gaseous exchange by neurological system process [IMP]
- regulation of smooth muscle contraction [IMP]
- regulation of striated muscle contraction [IMP]
- regulation of the force of heart contraction [IMP]
- regulation of vasoconstriction [IGI, IMP]
- response to glycoside [IMP, ISO]
- response to nicotine [ISO]
- sodium ion export from cell [ISO]
- sodium ion transmembrane transport [ISO]
- sodium ion transport [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CUL3
AI467304, AW146203, mKIAA0617
cullin 3
GO Process (26)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- COPII vesicle coating [ISO]
- ER to Golgi vesicle-mediated transport [ISO]
- Wnt signaling pathway [IDA]
- cell migration [ISO]
- cell morphogenesis [IMP]
- embryonic cleavage [IMP]
- fibroblast apoptotic process [IMP]
- gastrulation [IMP]
- in utero embryonic development [IMP]
- integrin-mediated signaling pathway [IMP]
- liver morphogenesis [IMP]
- mitotic cell cycle [IMP]
- mitotic metaphase plate congression [ISO]
- negative regulation of Rho protein signal transduction [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of cytokinesis [ISO]
- positive regulation of mitotic metaphase/anaphase transition [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IGI, ISO]
- protein monoubiquitination [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI]
- stem cell division [IMP]
- stress fiber assembly [ISO]
- trophectodermal cellular morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.736 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID