BAIT
HSPA8
2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73, Hspa10
heat shock protein 8
GO Process (10)
GO Function (13)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- chaperone mediated protein folding requiring cofactor [IGI, ISO]
- chaperone-mediated protein folding [ISO]
- clathrin coat disassembly [IGI]
- negative regulation of fibril organization [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- protein folding [IDA]
- protein refolding [ISO]
- regulation of cell cycle [IDA]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IPI, ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IPI, ISO]
Gene Ontology Cellular Component
- Prp19 complex [ISO]
- blood microparticle [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [IDA, ISO]
- focal adhesion [ISO]
- intracellular [IDA]
- membrane [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [ISO]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
- ubiquitin ligase complex [ISO]
Mus musculus
PREY
DNAJC10
1200006L06Rik, D2Ertd706e, ERdj5, JPDI, RP23-282M14.2
DnaJ (Hsp40) homolog, subfamily C, member 10
GO Process (7)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA, ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISO]
- negative regulation of protein phosphorylation [ISO]
- oxidation-reduction process [ISO]
- positive regulation of ATPase activity [IMP]
- protein folding in endoplasmic reticulum [ISO]
- response to endoplasmic reticulum stress [ISO]
Gene Ontology Molecular Function- ATPase activator activity [IMP]
- ATPase binding [IPI, ISO]
- Hsp70 protein binding [ISO]
- chaperone binding [IDA, ISO]
- disulfide oxidoreductase activity [IDA]
- misfolded protein binding [ISO]
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [IDA]
- protein binding [IPI]
- protein disulfide oxidoreductase activity [IDA, ISO]
- ATPase activator activity [IMP]
- ATPase binding [IPI, ISO]
- Hsp70 protein binding [ISO]
- chaperone binding [IDA, ISO]
- disulfide oxidoreductase activity [IDA]
- misfolded protein binding [ISO]
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [IDA]
- protein binding [IPI]
- protein disulfide oxidoreductase activity [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.733 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID