BAIT
PRKACB
Pkacb
protein kinase, cAMP dependent, catalytic, beta
GO Process (6)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- negative regulation of meiotic cell cycle [ISO]
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IGI]
- neural tube closure [IGI]
- protein phosphorylation [IDA, ISO]
- regulation of protein processing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DYRK1A
2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, ENSMUSG00000074897, Gm10783, Mnbh, Mp86, mmb, RP24-424G16.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
GO Process (10)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- circadian rhythm [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of mRNA splicing, via spliceosome [IMP]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of protein deacetylation [IDA]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of alternative mRNA splicing, via spliceosome [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.729 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID