BAIT
PRDX6
1-cysPrx, 9430088D19Rik, AA690119, Aop2, Aop2-rs3, Brp-12, CC26, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGP, NSGPx, ORF06, Prdx5, Prdx6-rs3, aiPLA2, mKIAA0106
peroxiredoxin 6
GO Process (6)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GSTP1
GstpiB
glutathione S-transferase, pi 1
GO Process (22)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [IDA]
- common myeloid progenitor cell proliferation [IMP]
- glutathione metabolic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of JUN kinase activity [IDA, IMP]
- negative regulation of acute inflammatory response [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of biosynthetic process [IDA]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of leukocyte proliferation [IMP]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of neutrophil aggregation [NAS]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of peroxidase activity [IDA]
- negative regulation of stress-activated MAPK cascade [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- positive regulation of superoxide anion generation [IMP]
- regulation of ERK1 and ERK2 cascade [IDA]
- regulation of stress-activated MAPK cascade [IDA]
- response to reactive oxygen species [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.771 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID