BAIT
MAP2K4
JNKK1, MEK4, MKK4, PRKMK4, Sek1, Serk1, RP23-340L19.1
mitogen-activated protein kinase kinase 4
GO Process (10)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- JNK cascade [ISO]
- MAPK cascade [IPI]
- activation of JUN kinase activity [IBA, ISO]
- cell growth involved in cardiac muscle cell development [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of nitric-oxide synthase biosynthetic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HDLBP
1110005P14Rik, AA960365, AI118566, D1Ertd101e
high density lipoprotein (HDL) binding protein
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.709 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID