BAIT
PFN1
Pfn, DN-183N8.15-001
profilin 1
GO Process (15)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of actin filament bundle assembly [ISO]
- negative regulation of actin filament polymerization [ISO]
- negative regulation of stress fiber assembly [ISO]
- neural tube closure [IGI]
- positive regulation of ATPase activity [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of viral transcription [ISO]
- regulation of actin polymerization or depolymerization [TAS]
- regulation of transcription from RNA polymerase II promoter [IGI]
- sequestering of actin monomers [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ISG15
G1p2, IGI15, IP17, Irfp, UCRP
ISG15 ubiquitin-like modifier
GO Process (9)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- ISG15-protein conjugation [IDA, ISO]
- defense response to bacterium [IMP, ISO]
- defense response to virus [IMP, ISO]
- modification-dependent protein catabolic process [IDA]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of viral genome replication [ISO]
- positive regulation of erythrocyte differentiation [IMP]
- regulation of interferon-gamma production [ISO]
- response to type I interferon [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.819 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID