BAIT
CTBP1
BARS, CtBP1-L, CtBP1-S, CtBP3/BARS, D4S115h, D5H4S115, D5H4S115E
C-terminal binding protein 1
GO Process (10)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- Golgi organization [ISO]
- chromatin organization involved in regulation of transcription [ISO]
- negative regulation of histone H4 acetylation [ISO]
- negative regulation of histone acetylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of histone deacetylation [ISO]
- regulation of cell cycle [ISO]
- transcription from RNA polymerase II promoter [ISO]
- white fat cell differentiation [IDA]
Gene Ontology Molecular Function- NAD binding [ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- NAD binding [ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
KMT2A
6430520K01, ALL-1, All1, Cxxc7, HRX, HTRX1, Mll, Mll1, mKIAA4050
lysine (K)-specific methyltransferase 2A
GO Process (13)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- DNA methylation [IMP]
- anterior/posterior pattern specification [IGI, IMP]
- embryonic hemopoiesis [IMP]
- histone H3-K4 methylation [ISO]
- histone H3-K4 trimethylation [ISO]
- histone H4-K16 acetylation [ISO]
- negative regulation of cell proliferation [IMP]
- positive regulation of cellular response to drug [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transporter activity [ISO]
- protein complex assembly [ISO]
- regulation of histone H3-K4 methylation [IMP]
Gene Ontology Molecular Function- chromatin binding [IDA]
- histone methyltransferase activity (H3-K4 specific) [ISO]
- identical protein binding [ISO]
- lysine-acetylated histone binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transcription regulatory region DNA binding [ISO]
- unmethylated CpG binding [ISO]
- zinc ion binding [ISO]
- chromatin binding [IDA]
- histone methyltransferase activity (H3-K4 specific) [ISO]
- identical protein binding [ISO]
- lysine-acetylated histone binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transcription regulatory region DNA binding [ISO]
- unmethylated CpG binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.698 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID