BAIT
LAMTOR4
0910001L09Rik, AV006840
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LAMTOR1
2400001E08Rik, Pdro, p18
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
GO Process (15)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- cell growth [ISO]
- cellular protein localization [IMP, ISO]
- cellular response to amino acid stimulus [ISO]
- cholesterol homeostasis [ISO]
- endosome localization [IMP]
- endosome organization [IMP]
- lysosome localization [IMP]
- lysosome organization [IMP]
- positive regulation of GTPase activity [ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of TOR signaling [ISO]
- regulation of cholesterol efflux [ISO]
- regulation of cholesterol esterification [ISO]
- regulation of cholesterol import [ISO]
- regulation of receptor recycling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.966 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID