BAIT
EGFR
9030024J15Rik, AI552599, Erbb, Errb1, Errp, Wa5, wa-2, wa2, RP23-295E4.1
epidermal growth factor receptor
GO Process (55)
GO Function (19)
GO Component (15)
Gene Ontology Biological Process
- activation of MAPKK activity [ISO]
- astrocyte activation [ISO]
- cell morphogenesis [IGI]
- cell proliferation [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular response to amino acid stimulus [IDA]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to estradiol stimulus [ISO]
- cerebral cortex cell migration [IMP]
- digestive tract morphogenesis [IMP]
- embryonic placenta development [IMP]
- epidermal growth factor receptor signaling pathway [IDA, IGI, IMP, ISO]
- epidermis development [IMP]
- hair follicle development [IMP]
- intracellular signal transduction [ISO]
- learning or memory [ISO]
- magnesium ion homeostasis [ISO]
- morphogenesis of an epithelial fold [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein catabolic process [ISO]
- neuron projection morphogenesis [ISO]
- ovulation cycle [ISO]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IDA, IGI, ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of epithelial cell proliferation [IMP, ISO]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of inflammatory response [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of superoxide anion generation [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vasoconstriction [ISO]
- positive regulation of vasodilation [ISO]
- protein autophosphorylation [IDA, ISO]
- regulation of cell proliferation [IGI]
- regulation of nitric-oxide synthase activity [ISO]
- regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- response to UV-A [ISO]
- response to calcium ion [ISO]
- salivary gland morphogenesis [IMP]
- signal transduction [IDA, ISO]
- single organismal cell-cell adhesion [ISO]
- translation [ISO]
Gene Ontology Molecular Function- actin filament binding [ISO]
- chromatin binding [ISO]
- enzyme binding [ISO]
- epidermal growth factor binding [ISO]
- epidermal growth factor-activated receptor activity [IDA, ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- kinase activity [IDA]
- nitric-oxide synthase regulator activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [ISO]
- signal transducer activity [IDA]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- actin filament binding [ISO]
- chromatin binding [ISO]
- enzyme binding [ISO]
- epidermal growth factor binding [ISO]
- epidermal growth factor-activated receptor activity [IDA, ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- kinase activity [IDA]
- nitric-oxide synthase regulator activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [ISO]
- signal transducer activity [IDA]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- apical plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO]
- cell surface [IDA, ISO]
- cytoplasm [ISO]
- endocytic vesicle [IDA, ISO]
- endosome [ISO]
- endosome membrane [ISO]
- focal adhesion [ISO]
- intracellular [IDA]
- membrane [ISO]
- membrane raft [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
Mus musculus
PREY
LRP1
A2mr, AI316852, CD91, Lrp, b2b1554Clo
low density lipoprotein receptor-related protein 1
GO Process (17)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- aorta morphogenesis [IMP]
- apoptotic cell clearance [IMP]
- beta-amyloid clearance [IMP]
- cell proliferation [ISO]
- cholesterol metabolic process [IMP]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [IMP]
- negative regulation of smooth muscle cell migration [IMP]
- positive regulation of cholesterol efflux [IMP]
- positive regulation of lipid transport [IMP]
- positive regulation of protein transport [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISO]
- receptor-mediated endocytosis [IDA, ISO]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cholesterol transport [IMP]
- regulation of phospholipase A2 activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.742 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID