BAIT
TTR
AA408768, AI787086, D17860, prealbumin
transthyretin
GO Process (1)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MT3
Mt-3
metallothionein 3
GO Process (26)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- astrocyte development [IDA]
- cadmium ion homeostasis [IMP]
- cellular lipid catabolic process [IMP]
- cellular metal ion homeostasis [IDA]
- cellular response to oxidative stress [IDA]
- cellular zinc ion homeostasis [IDA, IMP]
- cholesterol catabolic process [IMP]
- energy reserve metabolic process [IMP]
- leptin-mediated signaling pathway [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of autophagy [IMP]
- negative regulation of necrotic cell death [IMP]
- negative regulation of neurogenesis [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell death [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of lysosomal membrane permeability [IMP]
- positive regulation of oxygen metabolic process [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of protein glycosylation [IMP]
- regulation of response to food [IMP]
- response to oxidative stress [IMP]
- zinc ion transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.742 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID