BAIT
WNK1
6430573H23Rik, EG406236, Hsn2, Prkwnk1, mKIAA0344
WNK lysine deficient protein kinase 1
GO Process (10)
GO Function (10)
GO Component (1)
Gene Ontology Biological Process
- intracellular signal transduction [ISO]
- ion transport [IDA]
- negative regulation of kinase activity [ISO]
- negative regulation of pancreatic juice secretion [IMP]
- negative regulation of phosphatase activity [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of systemic arterial blood pressure [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of cellular process [IDA]
Gene Ontology Molecular Function- ATP binding [ISO]
- chloride channel inhibitor activity [ISO]
- magnesium ion binding [ISO]
- phosphatase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein serine/threonine kinase inhibitor activity [ISO]
- ATP binding [ISO]
- chloride channel inhibitor activity [ISO]
- magnesium ion binding [ISO]
- phosphatase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein serine/threonine kinase inhibitor activity [ISO]
Mus musculus
PREY
MYH9
Fltn, Myhn-1, Myhn1, NMHCIIA, NMMHC-A, NMMHC-IIA, TU72.6, AL583886.1
myosin, heavy polypeptide 9, non-muscle
GO Process (22)
GO Function (11)
GO Component (26)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- actin cytoskeleton reorganization [ISO]
- actin filament-based movement [ISO]
- actomyosin structure organization [ISO]
- angiogenesis [ISO]
- blood vessel endothelial cell migration [ISO]
- cell adhesion [IMP]
- cell morphogenesis involved in differentiation [IMP]
- cellular component movement [IMP]
- cytokinesis [ISO]
- establishment of T cell polarity [IMP]
- establishment of meiotic spindle localization [IDA]
- in utero embryonic development [IMP]
- meiotic spindle organization [IDA]
- membrane protein ectodomain proteolysis [ISO]
- myoblast fusion [IMP]
- platelet aggregation [ISO]
- platelet formation [ISO]
- protein transport [ISO]
- regulation of cell shape [IMP, ISO]
- single organismal cell-cell adhesion [IMP]
- uropod organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- actin cytoskeleton [ISO]
- actomyosin [ISO]
- actomyosin contractile ring [ISO]
- cell cortex [IDA]
- cell leading edge [ISO]
- cell-cell adherens junction [IDA]
- cleavage furrow [ISO]
- cortical cytoskeleton [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA, ISO]
- integrin complex [ISO]
- membrane [ISO]
- myosin II complex [IDA, ISO]
- myosin II filament [ISO]
- myosin complex [IDA]
- neuromuscular junction [IDA]
- nucleus [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- ruffle [ISO]
- spindle [IDA]
- stress fiber [IDA, ISO]
- uropod [IDA, ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.683 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID