BAIT
ACHE
acetylcholinesterase
GO Process (13)
GO Function (10)
GO Component (20)
Gene Ontology Biological Process
- acetylcholine catabolic process [IDA, ISO]
- acetylcholine metabolic process [ISO]
- cell adhesion [ISO]
- choline metabolic process [ISO]
- neuron death [ISO]
- neurotransmitter receptor biosynthetic process [IMP]
- positive regulation of axonogenesis [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- protein tetramerization [IDA]
- receptor internalization [IMP]
- regulation of receptor recycling [IMP]
- retina development in camera-type eye [IMP]
- synapse assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- axon [ISO]
- basal lamina [IDA]
- cell surface [IDA, ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- endoplasmic reticulum lumen [ISO]
- extracellular region [ISO]
- extracellular space [IDA]
- membrane [ISO]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nuclear envelope [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [ISO]
- presynaptic membrane [ISO]
- rough endoplasmic reticulum [ISO]
- synapse [IDA, ISO]
Mus musculus
PREY
NLGN3
A230085M13Rik, HNL3, NL3, RP23-440J15.4
neuroligin 3
GO Process (28)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- adult behavior [ISO]
- axon extension [ISO]
- learning [ISO]
- neuron cell-cell adhesion [IBA, ISO]
- oligodendrocyte differentiation [IMP]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of synapse assembly [ISO]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic membrane assembly [IMP]
- presynaptic membrane assembly [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of inhibitory postsynaptic membrane potential [IMP, ISO]
- regulation of long-term synaptic potentiation [IMP]
- regulation of respiratory gaseous exchange by neurological system process [IGI]
- regulation of synaptic transmission [IGI]
- regulation of synaptic transmission, glutamatergic [IMP]
- regulation of terminal button organization [IMP]
- rhythmic synaptic transmission [ISO]
- social behavior [IMP, ISO]
- synapse assembly [ISO]
- synapse organization [IGI, ISO]
- visual learning [IMP]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.705 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID