HUWE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
OGT
Gene Ontology Biological Process
- apoptotic process [ISO]
- cellular response to glucose stimulus [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to retinoic acid [ISO]
- circadian regulation of gene expression [IMP]
- glucosamine metabolic process [ISO]
- histone H3-K4 trimethylation [ISO]
- histone H4-K16 acetylation [ISO]
- histone H4-K5 acetylation [ISO]
- histone H4-K8 acetylation [ISO]
- intracellular distribution of mitochondria [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cellular response to hypoxia [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of peptidyl-threonine phosphorylation [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein targeting to membrane [ISO]
- negative regulation of protein ubiquitination [IDA]
- phosphatidylinositol-mediated signaling [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell size [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of granulocyte differentiation [ISO]
- positive regulation of histone H3-K27 methylation [ISO]
- positive regulation of histone H3-K4 methylation [ISO]
- positive regulation of protein localization to nucleus [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of reactive oxygen species biosynthetic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein O-linked glycosylation [IDA, ISO, ISS, TAS]
- protein heterotrimerization [ISO]
- protein homotrimerization [ISO]
- regulation of Rac protein signal transduction [ISO]
- regulation of gluconeogenesis involved in cellular glucose homeostasis [IMP]
- regulation of glycolytic process [ISO]
- regulation of insulin receptor signaling pathway [ISO]
- response to insulin [ISO]
Gene Ontology Molecular Function- N-acetyltransferase activity [TAS]
- catalytic activity [ISS]
- enzyme activator activity [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO]
- histone acetyltransferase activity (H4-K5 specific) [ISO]
- histone acetyltransferase activity (H4-K8 specific) [ISO]
- monosaccharide binding [ISO]
- peptide binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- protein N-acetylglucosaminyltransferase activity [ISO]
- protein O-GlcNAc transferase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- transcription factor binding [ISO]
- N-acetyltransferase activity [TAS]
- catalytic activity [ISS]
- enzyme activator activity [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO]
- histone acetyltransferase activity (H4-K5 specific) [ISO]
- histone acetyltransferase activity (H4-K8 specific) [ISO]
- monosaccharide binding [ISO]
- peptide binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- protein N-acetylglucosaminyltransferase activity [ISO]
- protein O-GlcNAc transferase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- cytoplasm [ISO, TAS]
- cytosol [ISO]
- euchromatin [ISO]
- histone acetyltransferase complex [ISO]
- intracellular [TAS]
- microtubule organizing center [ISO]
- mitochondrion [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO, TAS]
- plasma membrane [ISO]
- zymogen granule [ISO]
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.737 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
HUWE1 OGT | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2340146 |
Curated By
- BioGRID