BAIT
PTPN5
Step
protein tyrosine phosphatase, non-receptor type 5
GO Process (2)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
PTPN2
AI325124, Ptpt, TC-PTP
protein tyrosine phosphatase, non-receptor type 2
GO Process (31)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- T cell differentiation [IMP]
- erythrocyte differentiation [IMP]
- glucose homeostasis [IMP]
- insulin receptor signaling pathway [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of chemotaxis [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of interferon-gamma-mediated signaling pathway [IMP]
- negative regulation of interleukin-2-mediated signaling pathway [IMP, ISO]
- negative regulation of interleukin-4-mediated signaling pathway [IMP, ISO]
- negative regulation of interleukin-6-mediated signaling pathway [IMP, ISO]
- negative regulation of lipid storage [IMP]
- negative regulation of macrophage colony-stimulating factor signaling pathway [IMP]
- negative regulation of macrophage differentiation [IMP]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [IMP]
- negative regulation of positive thymic T cell selection [IMP]
- negative regulation of prolactin signaling pathway [IMP]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IMP]
- negative regulation of type I interferon-mediated signaling pathway [IMP, ISO]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- negative regulation of tyrosine phosphorylation of Stat6 protein [IMP, ISO]
- peptidyl-tyrosine dephosphorylation [IMP, ISO]
- positive regulation of gluconeogenesis [IMP]
- protein dephosphorylation [IMP]
- regulation of hepatocyte growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.779 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID