BAIT
CASK
DXPri1, DXRib1, LIN-2, Pals3, mLin-2, RP23-278L4.1
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
GO Process (8)
GO Function (5)
GO Component (18)
Gene Ontology Biological Process
- calcium ion import [IMP]
- intracellular protein transport [ISO]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of cellular response to growth factor stimulus [ISO]
- negative regulation of keratinocyte proliferation [ISO]
- negative regulation of wound healing [ISO]
- positive regulation of calcium ion import [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basement membrane [IDA, ISO]
- basolateral plasma membrane [IDA]
- cell-cell junction [IDA, ISO]
- ciliary membrane [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- dendrite [ISO]
- focal adhesion [ISO]
- membrane [IDA, ISO]
- nuclear lamina [ISO]
- nuclear matrix [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- presynaptic membrane [ISO]
- protein complex [ISO]
- synapse [IDA]
- synaptic membrane [ISO]
Mus musculus
PREY
RAB3A
RAB3A, member RAS oncogene family
GO Process (21)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- axonogenesis [IMP]
- intracellular protein transport [IBA]
- lung development [IMP]
- maintenance of presynaptic active zone structure [IMP]
- mitochondrion organization [IMP]
- neuromuscular synaptic transmission [IMP]
- positive regulation of ATPase activity [ISO]
- positive regulation of regulated secretory pathway [ISO]
- post-embryonic development [IMP]
- protein secretion [IBA]
- regulation of exocytosis [IDA]
- regulation of synaptic vesicle fusion to presynaptic membrane [IMP]
- respiratory system process [IMP]
- response to electrical stimulus [IMP]
- sensory perception of touch [IMP]
- synaptic vesicle exocytosis [IMP, ISO]
- synaptic vesicle maturation [IMP]
- synaptic vesicle recycling [ISO]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.805 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID