BAIT
SOD1
B430204E11Rik, Cu/Zn-SOD, CuZnSOD, Ipo-1, Ipo1, SODC, Sod-1
superoxide dismutase 1, soluble
GO Process (50)
GO Function (9)
GO Component (22)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- aging [IMP]
- anterograde axon cargo transport [IMP]
- auditory receptor cell stereocilium organization [IMP]
- cell aging [ISO]
- cellular iron ion homeostasis [IMP]
- embryo implantation [IMP]
- glutathione metabolic process [IMP]
- heart contraction [IMP, ISO]
- hydrogen peroxide biosynthetic process [IMP, ISO]
- locomotory behavior [IMP]
- muscle cell cellular homeostasis [IMP]
- myeloid cell homeostasis [IGI, IMP]
- negative regulation of apoptotic process [IDA, IMP, ISO]
- negative regulation of cholesterol biosynthetic process [ISO]
- negative regulation of neuron apoptotic process [IMP]
- neurofilament cytoskeleton organization [IGI, IMP]
- ovarian follicle development [IMP]
- oxidation-reduction process [IMP]
- peripheral nervous system myelin maintenance [IMP]
- positive regulation of catalytic activity [ISO]
- positive regulation of cytokine production [ISO]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of superoxide anion generation [ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of Rac GTPase activity [ISO]
- regulation of blood pressure [IMP]
- regulation of mitochondrial membrane potential [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of protein kinase activity [ISO]
- relaxation of vascular smooth muscle [IMP]
- removal of superoxide radicals [IDA, IGI, IMP, ISO, TAS]
- response to axon injury [IMP]
- response to copper ion [ISO]
- response to drug [IMP]
- response to ethanol [IMP]
- response to heat [IMP]
- response to hydrogen peroxide [IMP]
- response to nutrient levels [ISO]
- response to organic substance [ISO]
- response to oxidative stress [IDA, IMP, ISO]
- response to reactive oxygen species [IMP]
- response to superoxide [IMP, ISO]
- retina homeostasis [IMP]
- retrograde axon cargo transport [IMP]
- sensory perception of sound [IMP]
- spermatogenesis [IMP]
- superoxide anion generation [IDA]
- superoxide metabolic process [IMP, ISO]
- transmission of nerve impulse [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell [IMP]
- cytoplasm [ISO, TAS]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- dendrite cytoplasm [ISO]
- dense core granule [ISO]
- extracellular matrix [ISO]
- extracellular region [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- mitochondrial intermembrane space [ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- peroxisome [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- secretory granule [ISO]
Mus musculus
PREY
RAC1
AL023026, D5Ertd559e
RAS-related C3 botulinum substrate 1
GO Process (51)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IGI]
- GTP catabolic process [IDA, ISO]
- Wnt signaling pathway, planar cell polarity pathway [IGI]
- actin cytoskeleton organization [ISO]
- actin filament organization [ISO]
- actin filament polymerization [IDA]
- anatomical structure arrangement [IMP]
- auditory receptor cell morphogenesis [IMP]
- axon guidance [IMP]
- bone resorption [ISO]
- cell adhesion [IDA]
- cell migration [IDA]
- cell motility [ISO]
- cell proliferation [ISO]
- cell-cell junction organization [IMP]
- cellular component movement [ISO]
- cerebral cortex radially oriented cell migration [IMP]
- chemotaxis [ISO]
- cochlea morphogenesis [IMP]
- cytoskeleton organization [IDA]
- dendrite development [IDA]
- dendrite morphogenesis [IGI]
- dopaminergic neuron differentiation [IGI]
- embryonic olfactory bulb interneuron precursor migration [IMP]
- endocytosis [IDA]
- engulfment of apoptotic cell [IDA]
- epithelial cell morphogenesis [IMP]
- hyperosmotic response [IDA]
- lamellipodium assembly [IDA, ISO, TAS]
- localization within membrane [ISO]
- mast cell chemotaxis [ISO]
- negative regulation of interleukin-23 production [ISO]
- phagocytosis, engulfment [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neutrophil chemotaxis [IMP, ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein localization to plasma membrane [IDA]
- regulation of cell migration [IMP, ISO]
- regulation of respiratory burst [ISO]
- ruffle assembly [IMP]
- ruffle organization [ISO]
- semaphorin-plexin signaling pathway [ISO]
- small GTPase mediated signal transduction [IDA]
- substrate adhesion-dependent cell spreading [IDA, IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [ISO]
- actin filament [ISO]
- cell projection [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [IDA]
- focal adhesion [ISO]
- lamellipodium [IDA, ISO]
- membrane [IDA, ISO]
- phagocytic cup [IDA]
- ruffle membrane [IDA]
- trans-Golgi network [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.763 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID