GNB1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO, TAS]
- GTP catabolic process [ISA, ISO]
- cardiac muscle cell apoptotic process [ISO]
- cell proliferation [IDA]
- cellular response to hypoxia [ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- phototransduction, visible light [ISA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- retina development in camera-type eye [IMP]
- sensory perception of taste [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GNB2L1
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- intracellular signal transduction [ISA]
- negative regulation of cell growth [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of hydrogen peroxide-induced neuron death [ISO]
- negative regulation of phagocytosis [ISO]
- negative regulation of protein kinase B signaling [ISO]
- negative regulation of protein tyrosine kinase activity [ISO]
- negative regulation of translation [ISO]
- osteoblast differentiation [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cAMP catabolic process [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of mitochondrial depolarization [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein homooligomerization [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein localization [ISA]
- regulation of cell cycle [ISO]
- regulation of establishment of protein localization to plasma membrane [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISO]
- enzyme binding [ISO]
- ion channel inhibitor activity [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISA, ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase inhibitor activity [ISO]
- receptor activity [ISA]
- receptor tyrosine kinase binding [ISO]
- SH2 domain binding [ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISO]
- enzyme binding [ISO]
- ion channel inhibitor activity [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISA, ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase inhibitor activity [ISO]
- receptor activity [ISA]
- receptor tyrosine kinase binding [ISO]
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.727 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GNB1 GNB2L1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | High | - | BioGRID | - |
Curated By
- BioGRID