BAIT
PPP3CB
1110063J16Rik, Calnb, CnAbeta, Cnab
protein phosphatase 3, catalytic subunit, beta isoform
GO Process (19)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- T cell differentiation [IMP]
- T cell homeostasis [IMP]
- calcineurin-NFAT signaling cascade [ISO]
- calcium ion-dependent exocytosis [IDA]
- cellular response to drug [ISO]
- dephosphorylation [IDA]
- heart development [IMP]
- locomotion involved in locomotory behavior [IMP]
- lymphangiogenesis [IGI]
- negative regulation of T cell mediated cytotoxicity [IMP]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein dephosphorylation [IMP, ISO]
- protein phosphorylation [IMP]
- regulation of gene expression [IMP]
- regulation of insulin secretion [ISO]
- response to cytokine [IMP]
- response to stress [IMP]
Gene Ontology Molecular Function- calcium ion binding [ISO]
- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [IMP]
- drug binding [ISO]
- enzyme binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein phosphatase 2B binding [ISO]
- protein serine/threonine phosphatase activity [IDA]
- calcium ion binding [ISO]
- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [IMP]
- drug binding [ISO]
- enzyme binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein phosphatase 2B binding [ISO]
- protein serine/threonine phosphatase activity [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
SLC8A1
AI852629, AV344025, D930008O12Rik, Ncx1
solute carrier family 8 (sodium/calcium exchanger), member 1
GO Process (38)
GO Function (6)
GO Component (17)
Gene Ontology Biological Process
- calcium ion export [IMP, ISO]
- calcium ion homeostasis [IMP]
- calcium ion import [IMP, ISO]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, IMP]
- calcium ion transport into cytosol [IMP, ISO]
- cardiac muscle cell development [IMP]
- cardiac muscle contraction [IGI]
- cell communication by electrical coupling involved in cardiac conduction [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to cAMP [ISO]
- cellular response to caffeine [IMP]
- cellular response to reactive oxygen species [ISO]
- cellular sodium ion homeostasis [ISO]
- embryonic heart tube development [IMP]
- embryonic placenta development [IMP]
- heart morphogenesis [IGI]
- muscle fiber development [IGI]
- negative regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of the force of heart contraction [ISO]
- post-embryonic development [IGI]
- regulation of calcium ion transport [ISO]
- regulation of cardiac muscle cell membrane potential [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISO]
- regulation of heart rate [IMP]
- regulation of sodium ion transport [ISO]
- regulation of the force of heart contraction [IMP]
- relaxation of smooth muscle [IMP]
- response to ATP [ISO]
- response to hypoxia [ISO]
- response to muscle stretch [ISO]
- sodium ion export [IMP, ISO]
- sodium ion import [IMP, ISO]
- sodium ion transmembrane transport [IDA]
- sodium ion transport [IDA, ISO]
- vascular smooth muscle contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA, ISO]
- Z disc [ISO]
- basolateral plasma membrane [IDA]
- cell [IMP]
- cell projection [ISO]
- cytosol [IMP]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- integral component of membrane [TAS]
- integral component of plasma membrane [ISO]
- intercalated disc [ISO]
- intracellular [IMP]
- membrane [IDA]
- microtubule [ISO]
- mitochondrion [ISO]
- plasma membrane [IDA, ISO]
- sarcolemma [IDA, ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.906 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID