BAIT
MAPK1
9030612K14Rik, AA407128, AU018647, C78273, ERK, Erk2, MAPK2, PRKM2, Prkm1, p41mapk, p42mapk
mitogen-activated protein kinase 1
GO Process (35)
GO Function (12)
GO Component (18)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IDA, IMP, ISO]
- MAPK import into nucleus [ISO]
- T cell receptor signaling pathway [IDA]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to organic substance [ISO]
- cytosine metabolic process [IDA]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [IMP]
- lipopolysaccharide-mediated signaling pathway [IDA]
- mammary gland epithelial cell proliferation [IDA]
- negative regulation of cell differentiation [IGI]
- organ morphogenesis [IDA]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of translation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [NAS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO]
- response to estrogen [ISO]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to toxic substance [ISO]
- sensory perception of pain [ISO]
- signal transduction [ISO]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- MAP kinase activity [IDA, IMP, ISO]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- kinase activity [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatase binding [ISO]
- phosphotyrosine binding [IMP]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ATP binding [ISO]
- MAP kinase activity [IDA, IMP, ISO]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- kinase activity [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatase binding [ISO]
- phosphotyrosine binding [IMP]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [ISO]
- caveola [TAS]
- cytoplasm [IDA, ISO]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [ISO]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [IDA, TAS]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, TAS]
- perikaryon [ISO]
- protein complex [ISO]
- pseudopodium [IDA]
Mus musculus
PREY
SLC9A1
AW554487, Apnh, Nhe1, swe, RP23-32C12.6
solute carrier family 9 (sodium/hydrogen exchanger), member 1
GO Process (33)
GO Function (3)
GO Component (18)
Gene Ontology Biological Process
- cardiac muscle cell differentiation [IMP]
- cellular response to acidic pH [ISO]
- cellular response to epinephrine stimulus [ISO]
- cellular response to hypoxia [ISO]
- cellular response to insulin stimulus [ISO]
- cellular sodium ion homeostasis [ISO]
- embryo development [IMP]
- hydrogen ion transmembrane transport [IMP, ISO]
- negative regulation of apoptotic process [ISO]
- neuron death [ISO]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of action potential [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of calcineurin-NFAT signaling cascade [ISO]
- positive regulation of calcium:sodium antiporter activity [ISO]
- positive regulation of cardiac muscle hypertrophy [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of mitochondrial membrane permeability [ISO]
- positive regulation of the force of heart contraction [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of cardiac muscle contraction by calcium ion signaling [ISO]
- regulation of intracellular pH [ISO]
- regulation of pH [IDA, IMP, ISO]
- regulation of sensory perception of pain [ISO]
- regulation of the force of heart contraction [ISO]
- regulation of the force of heart contraction by cardiac conduction [ISO]
- response to acidic pH [IMP, ISO]
- response to muscle stretch [ISO]
- response to organic cyclic compound [ISO]
- sodium ion import across plasma membrane [ISO]
- sodium ion transmembrane transport [IMP]
- sodium ion transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- apical plasma membrane [IDA]
- basolateral plasma membrane [ISO, TAS]
- cation-transporting ATPase complex [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of plasma membrane [ISO]
- intercalated disc [ISO]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrion [ISO]
- nucleoplasm [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- sarcolemma [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.73 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID