BAIT
CAPN1
Capa-1, Capa1, mu-calpin
calpain 1
GO Process (4)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SLC9A3R1
EBP-50, NHE-RF, NHERF-1, NHERF1, RP23-342L24.4
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
GO Process (26)
GO Function (13)
GO Component (19)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- adenylate cyclase-activating dopamine receptor signaling pathway [IMP]
- auditory receptor cell stereocilium organization [IMP]
- bile acid secretion [IMP]
- cAMP-mediated signaling [IMP, ISA]
- cellular phosphate ion homeostasis [IMP]
- cellular protein localization [IMP]
- glutathione transport [IMP]
- microvillus assembly [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of cell migration [IGI]
- negative regulation of cell motility [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [IGI, IMP]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IMP]
- negative regulation of protein kinase B signaling [IMP, ISO]
- negative regulation of sodium ion transport [IMP]
- negative regulation of sodium:proton antiporter activity [IMP]
- phospholipase C-activating dopamine receptor signaling pathway [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- regulation of excretion [IMP]
- regulation of protein kinase activity [IMP]
- renal absorption [IMP]
- renal phosphate ion absorption [ISO]
- renal sodium ion transport [IMP]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- beta-catenin binding [ISO]
- chloride channel regulator activity [ISO]
- dopamine receptor binding [IDA]
- growth factor receptor binding [ISO]
- phosphatase binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- protein domain specific binding [ISO]
- protein self-association [ISO]
- receptor binding [ISO]
- PDZ domain binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- beta-catenin binding [ISO]
- chloride channel regulator activity [ISO]
- dopamine receptor binding [IDA]
- growth factor receptor binding [ISO]
- phosphatase binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- protein domain specific binding [ISO]
- protein self-association [ISO]
- receptor binding [ISO]
Gene Ontology Cellular Component
- apical part of cell [IDA]
- apical plasma membrane [IDA, ISO]
- brush border membrane [IDA]
- cell [IMP]
- cell periphery [ISO]
- centrosome [ISO]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- microvillus [ISO]
- microvillus membrane [ISO]
- plasma membrane [ISO]
- sperm midpiece [IDA]
- stereocilium [IDA]
- stereocilium bundle tip [IDA]
- vesicle [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.713 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID