BAIT
NAPB
Brp14, E161, I47, SNARE, b-SNAP, RP23-377E1.3
N-ethylmaleimide sensitive fusion protein attachment protein beta
GO Process (5)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SYT1
AW124717, G630098F17Rik, SytI
synaptotagmin I
GO Process (9)
GO Function (15)
GO Component (13)
Gene Ontology Biological Process
- detection of calcium ion [ISO]
- neurotransmitter secretion [IDA]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of vesicle fusion [ISO]
- regulation of calcium ion-dependent exocytosis [ISO]
- regulation of regulated secretory pathway [ISO]
- response to calcium ion [ISO]
- synaptic vesicle exocytosis [IMP]
- vesicle docking [ISO]
Gene Ontology Molecular Function- SNARE binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [IPI, ISO]
- calmodulin binding [ISO]
- clathrin binding [ISO]
- identical protein binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [ISO]
- phosphatidylserine binding [ISO]
- phospholipid binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [ISO]
- SNARE binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [IPI, ISO]
- calmodulin binding [ISO]
- clathrin binding [ISO]
- identical protein binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [ISO]
- phosphatidylserine binding [ISO]
- phospholipid binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
- SNARE complex [ISO]
- cell [IMP]
- cytoplasm [ISO]
- dense core granule [ISO]
- excitatory synapse [ISO]
- intracellular organelle [ISO]
- neuron projection [IDA]
- plasma membrane [ISO, TAS]
- presynaptic membrane [IDA]
- secretory granule [IDA, ISO]
- synaptic vesicle [IDA, ISO, TAS]
- synaptic vesicle membrane [IDA]
- terminal bouton [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.75 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID