BAIT
HSPA1A
Hsp70-3, Hsp70.3, Hsp72, hsp68, hsp70A1
heat shock protein 1A
GO Process (5)
GO Function (14)
GO Component (19)
Gene Ontology Biological Process
Gene Ontology Molecular Function- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [ISO]
- G-protein coupled receptor binding [ISO]
- NF-kappaB binding [ISO]
- double-stranded RNA binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [ISO]
- protein N-terminus binding [ISO]
- protein binding involved in protein folding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [ISO]
- G-protein coupled receptor binding [ISO]
- NF-kappaB binding [ISO]
- double-stranded RNA binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [ISO]
- protein N-terminus binding [ISO]
- protein binding involved in protein folding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- aggresome [ISO]
- apical plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- blood microparticle [ISO]
- centriole [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- inclusion body [ISO]
- mitochondrion [ISS]
- nuclear speck [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [ISO]
- ubiquitin ligase complex [ISO]
- vesicle [ISO]
Mus musculus
PREY
TRIAP1
1810015M01Rik, AU020874, AU043831, P53csv, Wf-1
TP53 regulated inhibitor of apoptosis 1
GO Process (10)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [ISO]
- cellular response to UV [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- phospholipid transport [ISO]
- positive regulation of phospholipid transport [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of membrane lipid distribution [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.75 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID