BAIT
TULP3
2310022L06Rik, AI316887
tubby-like protein 3
GO Process (20)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- anterior/posterior pattern specification [IMP]
- bone development [IMP]
- brain development [IMP]
- bronchus morphogenesis [IMP]
- central nervous system neuron differentiation [IMP]
- dorsal/ventral neural tube patterning [IMP]
- embryonic camera-type eye development [IMP]
- embryonic digit morphogenesis [IMP]
- embryonic neurocranium morphogenesis [IMP]
- ganglion development [IMP]
- limb development [IGI, IMP]
- negative regulation of smoothened signaling pathway [IMP, ISO]
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IMP]
- negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [IMP]
- neural tube closure [IMP]
- neural tube development [IMP]
- neural tube formation [IMP]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of smoothened signaling pathway [IMP]
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WNK1
6430573H23Rik, EG406236, Hsn2, Prkwnk1, mKIAA0344
WNK lysine deficient protein kinase 1
GO Process (10)
GO Function (10)
GO Component (1)
Gene Ontology Biological Process
- intracellular signal transduction [ISO]
- ion transport [IDA]
- negative regulation of kinase activity [ISO]
- negative regulation of pancreatic juice secretion [IMP]
- negative regulation of phosphatase activity [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of systemic arterial blood pressure [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of cellular process [IDA]
Gene Ontology Molecular Function- ATP binding [ISO]
- chloride channel inhibitor activity [ISO]
- magnesium ion binding [ISO]
- phosphatase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein serine/threonine kinase inhibitor activity [ISO]
- ATP binding [ISO]
- chloride channel inhibitor activity [ISO]
- magnesium ion binding [ISO]
- phosphatase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein serine/threonine kinase inhibitor activity [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.73 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID