BAIT
SHROOM2
4832440C16, Apxl, C630003H05Rik, Shrm2, RP23-392C8.1
shroom family member 2
GO Process (15)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- actin filament bundle assembly [IDA]
- apical protein localization [ISS]
- brain development [ISS]
- camera-type eye development [ISS]
- camera-type eye morphogenesis [ISS]
- cell migration [IMP]
- cell morphogenesis [IDA]
- cell-cell junction maintenance [IDA]
- cellular pigment accumulation [ISS]
- ear development [ISS]
- establishment of melanosome localization [ISS]
- eye pigment granule organization [ISS]
- lens morphogenesis in camera-type eye [ISS]
- melanosome organization [IMP]
- negative regulation of actin filament depolymerization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical junction complex [IDA]
- apical plasma membrane [IDA, ISS]
- cell cortex [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA]
- cortical actin cytoskeleton [IDA, ISO]
- cytoplasm [IDA]
- cytoskeleton [IDA]
- extracellular vesicular exosome [ISO]
- filamentous actin [IDA]
- neuronal cell body [IDA]
- plasma membrane [IDA]
- tight junction [IDA]
Mus musculus
PREY
YWHAE
AU019196, RP23-78H4.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
GO Process (8)
GO Function (12)
GO Component (6)
Gene Ontology Biological Process
- cerebral cortex development [IMP]
- hippocampus development [IMP]
- negative regulation of peptidyl-serine dephosphorylation [ISO]
- negative regulation of protein dephosphorylation [IDA]
- neuron migration [IGI, IMP]
- protein targeting [IDA]
- regulation of membrane repolarization [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
Gene Ontology Molecular Function- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.793 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID