BAIT
ADD2
2900072M03Rik, add97
adducin 2 (beta)
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ADD1
AI256389
adducin 1 (alpha)
GO Process (14)
GO Function (8)
GO Component (14)
Gene Ontology Biological Process
- actin filament bundle assembly [ISO]
- barbed-end actin filament capping [ISO]
- cell morphogenesis [IMP]
- cell volume homeostasis [IMP]
- cellular response to retinoic acid [ISO]
- erythrocyte differentiation [IMP]
- hemoglobin metabolic process [IMP]
- homeostasis of number of cells within a tissue [IMP]
- in utero embryonic development [IMP]
- multicellular organism growth [IMP]
- negative regulation of actin filament polymerization [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of protein binding [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- F-actin capping protein complex [ISO]
- cell [IMP]
- cytoskeleton [IDA]
- dendrite [ISO]
- dendritic spine [ISO]
- focal adhesion [ISO]
- intermediate filament cytoskeleton [ISO]
- membrane [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
- synapse [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.932 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID