BAIT
ANXA2
AW215814, Cal1h, CT009708.1
annexin A2
GO Process (15)
GO Function (8)
GO Component (26)
Gene Ontology Biological Process
- angiogenesis [IMP]
- body fluid secretion [ISO]
- cellular response to acid chemical [IDA]
- collagen fibril organization [IMP]
- fibrinolysis [IMP]
- membrane budding [ISO]
- membrane raft assembly [ISO]
- negative regulation of catalytic activity [ISO]
- osteoclast development [ISO]
- positive regulation of binding [IMP]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of vesicle fusion [ISO]
- protein heterotetramerization [ISO]
- protein targeting to plasma membrane [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA]
- cell cortex [ISO]
- cell junction [ISS]
- cell surface [ISO]
- cytoplasm [IDA, ISO]
- early endosome [IDA]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [IDA]
- late endosome membrane [ISO]
- lipid particle [ISO]
- lysosomal membrane [ISO]
- macropinosome [ISO]
- membrane [ISO, ISS]
- membrane raft [ISO]
- midbody [ISO]
- myelin sheath adaxonal region [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- ruffle [ISO]
- sarcolemma [IDA]
- stress fiber [ISS]
- vesicle [ISO]
Mus musculus
PREY
ANXA1
Anx-1, Anx-A1, C430014K04Rik, Lpc-1, Lpc1
annexin A1
GO Process (25)
GO Function (13)
GO Component (14)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA duplex unwinding [ISO]
- DNA rewinding [ISO]
- DNA strand renaturation [ISO]
- alpha-beta T cell differentiation [IMP]
- arachidonic acid secretion [IMP]
- cell surface receptor signaling pathway [ISO]
- cellular response to glucocorticoid stimulus [ISO]
- cellular response to hydrogen peroxide [ISO]
- insulin secretion [ISO]
- keratinocyte differentiation [ISO]
- negative regulation of interleukin-8 secretion [ISO]
- negative regulation of phospholipase A2 activity [ISO]
- negative regulation of protein secretion [ISO]
- neutrophil clearance [ISO]
- neutrophil homeostasis [IMP, ISO]
- peptide cross-linking [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of neutrophil apoptotic process [IMP]
- positive regulation of prostaglandin biosynthetic process [ISO]
- positive regulation of vesicle fusion [ISO]
- prolactin secretion [ISO]
- regulation of cell proliferation [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function- annealing helicase activity [ISO]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [ISO]
- helicase activity [ISO]
- phospholipase A2 inhibitor activity [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein homodimerization activity [ISO]
- single-stranded DNA binding [ISO]
- single-stranded RNA binding [ISO]
- structural molecule activity [ISO]
- annealing helicase activity [ISO]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [ISO]
- helicase activity [ISO]
- phospholipase A2 inhibitor activity [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein homodimerization activity [ISO]
- single-stranded DNA binding [ISO]
- single-stranded RNA binding [ISO]
- structural molecule activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.736 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID