BAIT
APOE
AI255918
apolipoprotein E
GO Process (84)
GO Function (19)
GO Component (28)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- N-methyl-D-aspartate receptor clustering [ISO]
- aging [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISO]
- artery morphogenesis [IGI]
- axon regeneration [IGI]
- cGMP-mediated signaling [ISO]
- cardiovascular system development [IMP]
- cellular calcium ion homeostasis [IDA]
- cholesterol biosynthetic process [IBA]
- cholesterol catabolic process [IMP]
- cholesterol efflux [IDA, IMP, ISO]
- cholesterol homeostasis [IGI, IMP, ISO]
- cholesterol metabolic process [IMP, ISO]
- chylomicron remnant clearance [ISO]
- fatty acid homeostasis [ISO]
- high-density lipoprotein particle assembly [IBA, ISO]
- high-density lipoprotein particle clearance [ISO]
- high-density lipoprotein particle remodeling [ISO]
- lipid homeostasis [IMP]
- lipid metabolic process [IGI]
- lipid transport [ISO]
- lipoprotein biosynthetic process [IGI]
- lipoprotein catabolic process [IMP]
- lipoprotein metabolic process [IGI, IMP, ISO]
- long-chain fatty acid transport [ISO]
- low-density lipoprotein particle remodeling [IMP]
- maintenance of location in cell [IMP]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of blood coagulation [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cholesterol biosynthetic process [ISO]
- negative regulation of cholesterol efflux [ISO]
- negative regulation of dendritic spine development [ISO]
- negative regulation of dendritic spine maintenance [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of inflammatory response [IGI]
- negative regulation of lipid biosynthetic process [ISO]
- negative regulation of lipid transport across blood brain barrier [ISO]
- negative regulation of neuron apoptotic process [IBA, ISO]
- negative regulation of neuron death [ISO]
- negative regulation of phospholipid efflux [ISO]
- negative regulation of platelet activation [ISO]
- negative regulation of postsynaptic membrane organization [ISO]
- negative regulation of presynaptic membrane organization [ISO]
- nitric oxide mediated signal transduction [ISO]
- phospholipid efflux [IBA, ISO]
- positive regulation of axon extension [ISO]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of cGMP biosynthetic process [ISO]
- positive regulation of catalytic activity [IMP]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of cholesterol esterification [IMP, ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of dendritic spine maintenance [ISO]
- positive regulation of lipid biosynthetic process [IBA, ISO]
- positive regulation of lipid transport across blood brain barrier [ISO]
- positive regulation of low-density lipoprotein particle receptor catabolic process [ISO]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric-oxide synthase activity [IBA, ISO]
- positive regulation of phospholipid efflux [ISO]
- positive regulation of postsynaptic membrane organization [ISO]
- positive regulation of presynaptic membrane organization [ISO]
- protein import [ISO]
- protein localization [IMP]
- receptor-mediated endocytosis [ISO]
- regulation of Cdc42 protein signal transduction [ISO]
- regulation of axon extension [IBA]
- regulation of beta-amyloid clearance [IBA, ISO]
- regulation of cholesterol transport [IBA]
- regulation of gene expression [IMP]
- regulation of neuron death [ISO]
- regulation of tau-protein kinase activity [ISO]
- response to dietary excess [IMP]
- response to oxidative stress [IMP]
- reverse cholesterol transport [IBA, ISO]
- triglyceride catabolic process [IBA]
- triglyceride metabolic process [ISO]
- vasodilation [IMP]
- very-low-density lipoprotein particle clearance [ISO]
- very-low-density lipoprotein particle remodeling [IMP, ISO]
Gene Ontology Molecular Function- antioxidant activity [ISO]
- beta-amyloid binding [IBA, ISO]
- cholesterol binding [IBA]
- cholesterol transporter activity [IDA]
- heparin binding [ISO]
- hydroxyapatite binding [ISO]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [ISO]
- lipoprotein particle binding [IDA]
- low-density lipoprotein particle receptor binding [IBA, ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IMP, ISO]
- phospholipid binding [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [IBA, ISO]
- antioxidant activity [ISO]
- beta-amyloid binding [IBA, ISO]
- cholesterol binding [IBA]
- cholesterol transporter activity [IDA]
- heparin binding [ISO]
- hydroxyapatite binding [ISO]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [ISO]
- lipoprotein particle binding [IDA]
- low-density lipoprotein particle receptor binding [IBA, ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IMP, ISO]
- phospholipid binding [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [IBA, ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- blood microparticle [IBA, ISO]
- cell [IDA]
- cell surface [ISO]
- chylomicron [IBA, ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- discoidal high-density lipoprotein particle [ISO]
- early endosome [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of external side of plasma membrane [ISO]
- high-density lipoprotein particle [IBA, ISO]
- intermediate-density lipoprotein particle [IBA, ISO]
- late endosome [ISO]
- low-density lipoprotein particle [IDA, ISO]
- lysosome [ISO]
- membrane [ISO]
- microtubule [ISO]
- neuronal cell body [ISO]
- nuclear envelope [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- very-low-density lipoprotein particle [ISO]
- vesicle [ISO]
Mus musculus
PREY
APOA1
Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep-2, Sep2, apo-AI, apoA-I
apolipoprotein A-I
GO Process (53)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- adrenal gland development [IMP]
- axon regeneration [IGI]
- blood vessel endothelial cell migration [IMP]
- cholesterol biosynthetic process [IMP]
- cholesterol efflux [IDA, IMP, ISO]
- cholesterol homeostasis [IBA, ISO]
- cholesterol import [ISO]
- cholesterol metabolic process [IGI, IMP, ISO]
- cholesterol transport [IDA, IMP, ISO]
- endothelial cell proliferation [IMP]
- glucocorticoid metabolic process [IMP]
- high-density lipoprotein particle assembly [IBA, ISO]
- integrin-mediated signaling pathway [ISO]
- lipid storage [IMP]
- lipoprotein biosynthetic process [IGI, IMP]
- negative chemotaxis [ISO]
- negative regulation of cell adhesion molecule production [ISO]
- negative regulation of cytokine secretion involved in immune response [ISO]
- negative regulation of heterotypic cell-cell adhesion [ISO]
- negative regulation of hydrolase activity [IGI]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-1 beta secretion [ISO]
- negative regulation of lipase activity [ISO]
- negative regulation of response to cytokine stimulus [ISO]
- negative regulation of tumor necrosis factor-mediated signaling pathway [ISO]
- negative regulation of very-low-density lipoprotein particle remodeling [ISO]
- organ regeneration [ISO]
- peptidyl-methionine modification [ISO]
- phosphatidylcholine biosynthetic process [ISO]
- phosphatidylcholine metabolic process [IBA]
- phospholipid efflux [IBA, ISO]
- phospholipid homeostasis [ISO]
- phospholipid metabolic process [IMP]
- phospholipid transport [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cholesterol esterification [IBA, ISO]
- positive regulation of fatty acid biosynthetic process [IBA]
- positive regulation of hydrolase activity [ISO]
- positive regulation of lipoprotein lipase activity [IBA]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- positive regulation of transferase activity [IMP]
- positive regulation of triglyceride catabolic process [IBA]
- protein localization [IMP]
- protein oxidation [ISO]
- protein stabilization [ISO]
- regulation of Cdc42 protein signal transduction [ISO]
- regulation of intestinal cholesterol absorption [IDA]
- regulation of protein phosphorylation [IDA]
- reverse cholesterol transport [IBA, ISO]
- triglyceride homeostasis [IBA, ISO]
- very-low-density lipoprotein particle remodeling [IBA]
Gene Ontology Molecular Function- apolipoprotein A-I receptor binding [ISO]
- apolipoprotein receptor binding [ISO]
- beta-amyloid binding [ISO]
- chemorepellent activity [ISO]
- cholesterol binding [IBA, ISO]
- cholesterol transporter activity [IDA, ISO]
- enzyme binding [ISO]
- high-density lipoprotein particle binding [IDA]
- high-density lipoprotein particle receptor binding [IBA, ISO]
- identical protein binding [IPI, ISO]
- lipase inhibitor activity [ISO]
- lipid binding [IDA]
- lipid transporter activity [IDA, IMP]
- lipoprotein particle binding [IDA]
- phosphatidylcholine binding [IBA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IBA, ISO]
- phospholipid binding [ISO]
- phospholipid transporter activity [ISO]
- protein binding [IPI]
- apolipoprotein A-I receptor binding [ISO]
- apolipoprotein receptor binding [ISO]
- beta-amyloid binding [ISO]
- chemorepellent activity [ISO]
- cholesterol binding [IBA, ISO]
- cholesterol transporter activity [IDA, ISO]
- enzyme binding [ISO]
- high-density lipoprotein particle binding [IDA]
- high-density lipoprotein particle receptor binding [IBA, ISO]
- identical protein binding [IPI, ISO]
- lipase inhibitor activity [ISO]
- lipid binding [IDA]
- lipid transporter activity [IDA, IMP]
- lipoprotein particle binding [IDA]
- phosphatidylcholine binding [IBA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IBA, ISO]
- phospholipid binding [ISO]
- phospholipid transporter activity [ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- blood microparticle [IBA, ISO]
- cell surface [ISO]
- chylomicron [IBA]
- cytoplasmic vesicle [ISO]
- discoidal high-density lipoprotein particle [ISO]
- endocytic vesicle [ISO]
- extracellular region [IDA]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- high-density lipoprotein particle [IBA, ISO]
- nucleus [ISO]
- spherical high-density lipoprotein particle [ISO]
- very-low-density lipoprotein particle [ISO]
- vesicle [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.8335 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| APOA1 APOE | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 872759 |
Curated By
- BioGRID