BAIT
PRNP
AA960666, AI325101, CD230, PrP, PrP, PrPC, PrPSc, Prn-i, Prn-p, Sinc, prP27-30, prP33-35C, RP23-401J24.1
prion protein
GO Process (19)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- cellular copper ion homeostasis [TAS]
- cellular response to copper ion [ISO]
- cellular response to drug [IDA]
- learning or memory [ISO]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of apoptotic process [IGI, ISO]
- negative regulation of calcineurin-NFAT signaling cascade [IMP]
- negative regulation of interferon-gamma production [IMP]
- negative regulation of interleukin-17 production [IMP]
- negative regulation of interleukin-2 production [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- nucleobase-containing compound metabolic process [TAS]
- regulation of potassium ion transmembrane transport [IGI]
- regulation of protein localization [IMP]
- response to cadmium ion [ISO]
- response to copper ion [ISO]
- response to oxidative stress [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
APOE
AI255918
apolipoprotein E
GO Process (84)
GO Function (19)
GO Component (28)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- N-methyl-D-aspartate receptor clustering [ISO]
- aging [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISO]
- artery morphogenesis [IGI]
- axon regeneration [IGI]
- cGMP-mediated signaling [ISO]
- cardiovascular system development [IMP]
- cellular calcium ion homeostasis [IDA]
- cholesterol biosynthetic process [IBA]
- cholesterol catabolic process [IMP]
- cholesterol efflux [IDA, IMP, ISO]
- cholesterol homeostasis [IGI, IMP, ISO]
- cholesterol metabolic process [IMP, ISO]
- chylomicron remnant clearance [ISO]
- fatty acid homeostasis [ISO]
- high-density lipoprotein particle assembly [IBA, ISO]
- high-density lipoprotein particle clearance [ISO]
- high-density lipoprotein particle remodeling [ISO]
- lipid homeostasis [IMP]
- lipid metabolic process [IGI]
- lipid transport [ISO]
- lipoprotein biosynthetic process [IGI]
- lipoprotein catabolic process [IMP]
- lipoprotein metabolic process [IGI, IMP, ISO]
- long-chain fatty acid transport [ISO]
- low-density lipoprotein particle remodeling [IMP]
- maintenance of location in cell [IMP]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of blood coagulation [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cholesterol biosynthetic process [ISO]
- negative regulation of cholesterol efflux [ISO]
- negative regulation of dendritic spine development [ISO]
- negative regulation of dendritic spine maintenance [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of inflammatory response [IGI]
- negative regulation of lipid biosynthetic process [ISO]
- negative regulation of lipid transport across blood brain barrier [ISO]
- negative regulation of neuron apoptotic process [IBA, ISO]
- negative regulation of neuron death [ISO]
- negative regulation of phospholipid efflux [ISO]
- negative regulation of platelet activation [ISO]
- negative regulation of postsynaptic membrane organization [ISO]
- negative regulation of presynaptic membrane organization [ISO]
- nitric oxide mediated signal transduction [ISO]
- phospholipid efflux [IBA, ISO]
- positive regulation of axon extension [ISO]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of cGMP biosynthetic process [ISO]
- positive regulation of catalytic activity [IMP]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of cholesterol esterification [IMP, ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of dendritic spine maintenance [ISO]
- positive regulation of lipid biosynthetic process [IBA, ISO]
- positive regulation of lipid transport across blood brain barrier [ISO]
- positive regulation of low-density lipoprotein particle receptor catabolic process [ISO]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric-oxide synthase activity [IBA, ISO]
- positive regulation of phospholipid efflux [ISO]
- positive regulation of postsynaptic membrane organization [ISO]
- positive regulation of presynaptic membrane organization [ISO]
- protein import [ISO]
- protein localization [IMP]
- receptor-mediated endocytosis [ISO]
- regulation of Cdc42 protein signal transduction [ISO]
- regulation of axon extension [IBA]
- regulation of beta-amyloid clearance [IBA, ISO]
- regulation of cholesterol transport [IBA]
- regulation of gene expression [IMP]
- regulation of neuron death [ISO]
- regulation of tau-protein kinase activity [ISO]
- response to dietary excess [IMP]
- response to oxidative stress [IMP]
- reverse cholesterol transport [IBA, ISO]
- triglyceride catabolic process [IBA]
- triglyceride metabolic process [ISO]
- vasodilation [IMP]
- very-low-density lipoprotein particle clearance [ISO]
- very-low-density lipoprotein particle remodeling [IMP, ISO]
Gene Ontology Molecular Function- antioxidant activity [ISO]
- beta-amyloid binding [IBA, ISO]
- cholesterol binding [IBA]
- cholesterol transporter activity [IDA]
- heparin binding [ISO]
- hydroxyapatite binding [ISO]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [ISO]
- lipoprotein particle binding [IDA]
- low-density lipoprotein particle receptor binding [IBA, ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IMP, ISO]
- phospholipid binding [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [IBA, ISO]
- antioxidant activity [ISO]
- beta-amyloid binding [IBA, ISO]
- cholesterol binding [IBA]
- cholesterol transporter activity [IDA]
- heparin binding [ISO]
- hydroxyapatite binding [ISO]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [ISO]
- lipoprotein particle binding [IDA]
- low-density lipoprotein particle receptor binding [IBA, ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IMP, ISO]
- phospholipid binding [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [IBA, ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- blood microparticle [IBA, ISO]
- cell [IDA]
- cell surface [ISO]
- chylomicron [IBA, ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- discoidal high-density lipoprotein particle [ISO]
- early endosome [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of external side of plasma membrane [ISO]
- high-density lipoprotein particle [IBA, ISO]
- intermediate-density lipoprotein particle [IBA, ISO]
- late endosome [ISO]
- low-density lipoprotein particle [IDA, ISO]
- lysosome [ISO]
- membrane [ISO]
- microtubule [ISO]
- neuronal cell body [ISO]
- nuclear envelope [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- very-low-density lipoprotein particle [ISO]
- vesicle [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.754 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRNP APOE | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID