BAIT
MAVS
D430028G21Rik, IPS-1, Visa, cardif, RP23-387C21.3
mitochondrial antiviral signaling protein
GO Process (24)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- RIG-I signaling pathway [IGI]
- activation of innate immune response [ISO]
- cellular response to exogenous dsRNA [ISO]
- defense response to bacterium [ISO]
- defense response to virus [ISO]
- innate immune response [ISO]
- negative regulation of viral genome replication [IMP, ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of IP-10 production [ISO]
- positive regulation of chemokine (C-C motif) ligand 5 production [ISO]
- positive regulation of defense response to virus by host [IMP, ISO]
- positive regulation of interferon-alpha production [ISO]
- positive regulation of interferon-beta production [ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of type I interferon production [IMP]
- positive regulation of type I interferon-mediated signaling pathway [ISO]
- regulation of peroxisome organization [IMP, ISO]
- signal transduction [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ATG5
2010107M05Rik, 3110067M24Rik, AW319544, Apg5l, Atg5l, C88337, Paddy
autophagy related 5
GO Process (23)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- autophagic vacuole assembly [IMP]
- autophagy [IMP]
- blood vessel remodeling [IMP]
- cellular response to nitrogen starvation [IBA]
- heart contraction [IMP]
- mitochondrion degradation [IBA]
- negative regulation of apoptotic process [IMP]
- negative regulation of histone H4-K16 acetylation [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative stranded viral RNA replication [IMP]
- nucleophagy [IBA]
- otolith development [IMP]
- positive regulation of mucus secretion [IMP]
- post-translational protein modification [IDA]
- regulation of cilium assembly [IMP]
- regulation of cytokine secretion involved in immune response [IMP]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of release of sequestered calcium ion into cytosol [IMP]
- response to drug [IMP]
- response to fungus [IMP]
- vasodilation [IMP]
- ventricular cardiac muscle cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.829 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID