MDH2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATP5B
Gene Ontology Biological Process
- ADP biosynthetic process [ISO]
- ATP biosynthetic process [ISO]
- ATP catabolic process [ISO]
- ATP metabolic process [ISO]
- angiogenesis [ISO]
- hydrogen ion transmembrane transport [ISO]
- lipid metabolic process [IMP]
- negative regulation of cell adhesion involved in substrate-bound cell migration [IMP]
- osteoblast differentiation [ISO]
- proton transport [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of intracellular pH [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- mitochondrial inner membrane [IDA, ISO]
- mitochondrial membrane [ISO]
- mitochondrial nucleoid [ISO]
- mitochondrial proton-transporting ATP synthase complex [ISO]
- mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- nucleus [ISO]
- plasma membrane [ISO]
- proton-transporting ATP synthase complex, catalytic core F(1) [ISO]
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.724 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MDH2 ATP5B | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | 3735544 | |
ATP5B MDH2 | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | 3735545 |
Curated By
- BioGRID