BAIT
IGFBP5
AI256729, AW208790, IGFBP-5, IGFBP-5P
insulin-like growth factor binding protein 5
GO Process (19)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- cellular response to cAMP [ISO]
- cellular response to organic cyclic compound [ISO]
- glucose homeostasis [IMP]
- glucose metabolic process [IMP]
- hair follicle morphogenesis [IMP]
- mammary gland involution [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of insulin-like growth factor receptor signaling pathway [IMP, ISO]
- negative regulation of osteoblast differentiation [IGI]
- negative regulation of smooth muscle cell migration [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of translation [ISO]
- positive regulation of insulin-like growth factor receptor signaling pathway [IGI]
- positive regulation of protein kinase B signaling [IMP]
- regulation of cell growth [IGI]
- regulation of glucose metabolic process [IGI]
- regulation of growth [IGI]
- striated muscle cell differentiation [IGI, IMP]
- type B pancreatic cell proliferation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BAG6
2410045D21Rik, AA408914, BAG-6, Bat3, D17H6S52E, G3, Scythe
BCL2-associated athanogene 6
GO Process (17)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- brain development [IMP]
- embryo development [IMP]
- internal peptidyl-lysine acetylation [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- kidney development [IMP]
- lung development [IMP]
- negative regulation of apoptotic process [IGI]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of proteolysis [IMP]
- protein stabilization [IMP]
- regulation of apoptotic process [IMP]
- spermatogenesis [IMP]
- synaptonemal complex assembly [IMP]
- tail-anchored membrane protein insertion into ER membrane [ISO]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7815 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID