BAIT
CLU
AI893575, ApoJ, Cli, D14Ucla3, SP-40, Sgp-2, Sgp2, Sugp-2
clusterin
GO Process (31)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- cell morphogenesis [ISO]
- central nervous system myelin maintenance [ISO]
- chaperone-mediated protein complex assembly [ISO]
- chaperone-mediated protein folding [ISO]
- endocrine pancreas development [ISO]
- intrinsic apoptotic signaling pathway [ISO]
- microglial cell activation [ISO]
- microglial cell proliferation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of protein homooligomerization [ISO]
- neuron projection morphogenesis [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of tau-protein kinase activity [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- protein import [ISO]
- protein stabilization [ISO]
- regulation of beta-amyloid clearance [ISO]
- regulation of neuron death [ISO]
- regulation of neuronal signal transduction [ISO]
- response to misfolded protein [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- aggresome [ISO]
- apical dendrite [ISO]
- blood microparticle [ISO]
- cytoplasm [ISO]
- extracellular matrix [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- growth cone [ISO]
- mitochondrion [ISO]
- neurofibrillary tangle [ISO]
- neuron projection [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- spherical high-density lipoprotein particle [ISO]
Mus musculus
PREY
BCL2L1
Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, RP23-106A3.4
BCL2-like 1
GO Process (41)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- apoptotic process in bone marrow [IMP]
- cell proliferation [IDA]
- cellular process regulating host cell cycle in response to virus [IMP]
- cellular response to alkaloid [IDA]
- cellular response to amino acid stimulus [IMP]
- cellular response to gamma radiation [IMP]
- cytokinesis [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- fertilization [IGI]
- germ cell development [IGI, IMP]
- growth [IMP]
- hepatocyte apoptotic process [IMP]
- in utero embryonic development [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- male gonad development [IMP]
- mitochondrion morphogenesis [IGI]
- mitotic cell cycle checkpoint [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IDA, IGI, IMP, ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of establishment of protein localization to plasma membrane [ISO]
- negative regulation of execution phase of apoptosis [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of neuron apoptotic process [IDA, IGI, IMP]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- neuron apoptotic process [IGI, IMP]
- ovarian follicle development [IGI, IMP, ISO]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of apoptotic process [ISO]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of mitochondrial membrane potential [ISO]
- release of cytochrome c from mitochondria [IGI, ISO]
- response to cycloheximide [IDA]
- response to cytokine [ISO]
- response to ischemia [ISO]
- response to radiation [IMP]
- response to virus [IDA]
- spermatogenesis [IGI]
- suppression by virus of host apoptotic process [ISO]
Gene Ontology Molecular Function- BH domain binding [ISO]
- BH3 domain binding [ISO]
- MDM2/MDM4 family protein binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA]
- protein kinase binding [ISO]
- BH domain binding [ISO]
- BH3 domain binding [ISO]
- MDM2/MDM4 family protein binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.777 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID