BAIT
CYFIP1
E030028J09Rik, P140SRA-1, P140sra1, Shyc, Sra-1, Sra1, l(7)1Rl, l71Rl, l7Rl1, mKIAA0068, pl-1
cytoplasmic FMR1 interacting protein 1
GO Process (5)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BRK1
6720456B07Rik, AW011779
BRICK1, SCAR/WAVE actin-nucleating complex subunit
GO Process (8)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- Rac protein signal transduction [ISO]
- actin cytoskeleton organization [IMP]
- cell motility [IMP]
- in utero embryonic development [IMP]
- positive regulation of Arp2/3 complex-mediated actin nucleation [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of lamellipodium assembly [ISO]
- protein homotrimerization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.913 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID