BAIT
GNAI2
C76432, Galphai2, Gia, Gnai-2
guanine nucleotide binding protein (G protein), alpha inhibiting 2
GO Process (14)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [IMP]
- G-protein coupled receptor signaling pathway [ISO]
- GTP catabolic process [IBA]
- activation of MAPKK activity [ISO]
- adenosine receptor signaling pathway [IBA, ISO]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IMP, ISA]
- cell division [ISO]
- cell proliferation [IPI]
- gamma-aminobutyric acid signaling pathway [IBA, ISO]
- intracellular signal transduction [ISO]
- negative regulation of synaptic transmission [ISO]
- positive regulation of cell proliferation [ISO]
- regulation of calcium ion transport [ISO]
- regulation of heart contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RLTPR
CG1399-PB, D130029J02Rik, Gm585
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
GO Process (9)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- establishment of protein localization [IMP]
- homeostasis of number of cells [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interferon-gamma secretion [IMP]
- positive regulation of interleukin-2 secretion [IMP]
- positive regulation of regulatory T cell differentiation [IMP]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7725 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID