BAIT
NEFL
AI847934, CMT2E, NF-L, NF68, Nfl
neurofilament, light polypeptide
GO Process (16)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- anterograde axon cargo transport [ISO]
- axon transport of mitochondrion [ISO]
- intermediate filament bundle assembly [IGI]
- intermediate filament organization [IMP, ISO]
- locomotion [IMP]
- microtubule cytoskeleton organization [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neurofilament bundle assembly [ISO]
- neurofilament cytoskeleton organization [IGI, IMP]
- neuromuscular process controlling balance [IMP]
- neuron projection morphogenesis [IMP]
- peripheral nervous system axon regeneration [IMP]
- positive regulation of axonogenesis [IMP]
- protein polymerization [ISO]
- regulation of axon diameter [IMP]
- retrograde axon cargo transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CDK5RAP2
2900018K03Rik, an, mKIAA1633, RP23-402H11.2
CDK5 regulatory subunit associated protein 2
GO Process (11)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- brain development [IMP]
- centrosome organization [ISO]
- chromosome segregation [ISO]
- establishment of mitotic spindle orientation [IMP]
- microtubule bundle formation [ISO]
- microtubule cytoskeleton organization [ISO]
- negative regulation of centriole replication [IMP]
- negative regulation of neuron differentiation [IMP]
- neurogenesis [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of spindle checkpoint [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.927 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID