BAIT
APOA1
Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep-2, Sep2, apo-AI, apoA-I
apolipoprotein A-I
GO Process (53)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- adrenal gland development [IMP]
- axon regeneration [IGI]
- blood vessel endothelial cell migration [IMP]
- cholesterol biosynthetic process [IMP]
- cholesterol efflux [IDA, IMP, ISO]
- cholesterol homeostasis [IBA, ISO]
- cholesterol import [ISO]
- cholesterol metabolic process [IGI, IMP, ISO]
- cholesterol transport [IDA, IMP, ISO]
- endothelial cell proliferation [IMP]
- glucocorticoid metabolic process [IMP]
- high-density lipoprotein particle assembly [IBA, ISO]
- integrin-mediated signaling pathway [ISO]
- lipid storage [IMP]
- lipoprotein biosynthetic process [IGI, IMP]
- negative chemotaxis [ISO]
- negative regulation of cell adhesion molecule production [ISO]
- negative regulation of cytokine secretion involved in immune response [ISO]
- negative regulation of heterotypic cell-cell adhesion [ISO]
- negative regulation of hydrolase activity [IGI]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-1 beta secretion [ISO]
- negative regulation of lipase activity [ISO]
- negative regulation of response to cytokine stimulus [ISO]
- negative regulation of tumor necrosis factor-mediated signaling pathway [ISO]
- negative regulation of very-low-density lipoprotein particle remodeling [ISO]
- organ regeneration [ISO]
- peptidyl-methionine modification [ISO]
- phosphatidylcholine biosynthetic process [ISO]
- phosphatidylcholine metabolic process [IBA]
- phospholipid efflux [IBA, ISO]
- phospholipid homeostasis [ISO]
- phospholipid metabolic process [IMP]
- phospholipid transport [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cholesterol esterification [IBA, ISO]
- positive regulation of fatty acid biosynthetic process [IBA]
- positive regulation of hydrolase activity [ISO]
- positive regulation of lipoprotein lipase activity [IBA]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- positive regulation of transferase activity [IMP]
- positive regulation of triglyceride catabolic process [IBA]
- protein localization [IMP]
- protein oxidation [ISO]
- protein stabilization [ISO]
- regulation of Cdc42 protein signal transduction [ISO]
- regulation of intestinal cholesterol absorption [IDA]
- regulation of protein phosphorylation [IDA]
- reverse cholesterol transport [IBA, ISO]
- triglyceride homeostasis [IBA, ISO]
- very-low-density lipoprotein particle remodeling [IBA]
Gene Ontology Molecular Function- apolipoprotein A-I receptor binding [ISO]
- apolipoprotein receptor binding [ISO]
- beta-amyloid binding [ISO]
- chemorepellent activity [ISO]
- cholesterol binding [IBA, ISO]
- cholesterol transporter activity [IDA, ISO]
- enzyme binding [ISO]
- high-density lipoprotein particle binding [IDA]
- high-density lipoprotein particle receptor binding [IBA, ISO]
- identical protein binding [IPI, ISO]
- lipase inhibitor activity [ISO]
- lipid binding [IDA]
- lipid transporter activity [IDA, IMP]
- lipoprotein particle binding [IDA]
- phosphatidylcholine binding [IBA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IBA, ISO]
- phospholipid binding [ISO]
- phospholipid transporter activity [ISO]
- protein binding [IPI]
- apolipoprotein A-I receptor binding [ISO]
- apolipoprotein receptor binding [ISO]
- beta-amyloid binding [ISO]
- chemorepellent activity [ISO]
- cholesterol binding [IBA, ISO]
- cholesterol transporter activity [IDA, ISO]
- enzyme binding [ISO]
- high-density lipoprotein particle binding [IDA]
- high-density lipoprotein particle receptor binding [IBA, ISO]
- identical protein binding [IPI, ISO]
- lipase inhibitor activity [ISO]
- lipid binding [IDA]
- lipid transporter activity [IDA, IMP]
- lipoprotein particle binding [IDA]
- phosphatidylcholine binding [IBA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IBA, ISO]
- phospholipid binding [ISO]
- phospholipid transporter activity [ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- blood microparticle [IBA, ISO]
- cell surface [ISO]
- chylomicron [IBA]
- cytoplasmic vesicle [ISO]
- discoidal high-density lipoprotein particle [ISO]
- endocytic vesicle [ISO]
- extracellular region [IDA]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- high-density lipoprotein particle [IBA, ISO]
- nucleus [ISO]
- spherical high-density lipoprotein particle [ISO]
- very-low-density lipoprotein particle [ISO]
- vesicle [ISO]
Mus musculus
PREY
CLU
AI893575, ApoJ, Cli, D14Ucla3, SP-40, Sgp-2, Sgp2, Sugp-2
clusterin
GO Process (31)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- cell morphogenesis [ISO]
- central nervous system myelin maintenance [ISO]
- chaperone-mediated protein complex assembly [ISO]
- chaperone-mediated protein folding [ISO]
- endocrine pancreas development [ISO]
- intrinsic apoptotic signaling pathway [ISO]
- microglial cell activation [ISO]
- microglial cell proliferation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of protein homooligomerization [ISO]
- neuron projection morphogenesis [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of tau-protein kinase activity [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- protein import [ISO]
- protein stabilization [ISO]
- regulation of beta-amyloid clearance [ISO]
- regulation of neuron death [ISO]
- regulation of neuronal signal transduction [ISO]
- response to misfolded protein [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- aggresome [ISO]
- apical dendrite [ISO]
- blood microparticle [ISO]
- cytoplasm [ISO]
- extracellular matrix [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- growth cone [ISO]
- mitochondrion [ISO]
- neurofibrillary tangle [ISO]
- neuron projection [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- spherical high-density lipoprotein particle [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.9075 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID