PRNP
Gene Ontology Biological Process
- cellular copper ion homeostasis [TAS]
- cellular response to copper ion [ISO]
- cellular response to drug [IDA]
- learning or memory [ISO]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of apoptotic process [IGI, ISO]
- negative regulation of calcineurin-NFAT signaling cascade [IMP]
- negative regulation of interferon-gamma production [IMP]
- negative regulation of interleukin-17 production [IMP]
- negative regulation of interleukin-2 production [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- nucleobase-containing compound metabolic process [TAS]
- regulation of potassium ion transmembrane transport [IGI]
- regulation of protein localization [IMP]
- response to cadmium ion [ISO]
- response to copper ion [ISO]
- response to oxidative stress [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLU
Gene Ontology Biological Process
- cell morphogenesis [ISO]
- central nervous system myelin maintenance [ISO]
- chaperone-mediated protein complex assembly [ISO]
- chaperone-mediated protein folding [ISO]
- endocrine pancreas development [ISO]
- intrinsic apoptotic signaling pathway [ISO]
- microglial cell activation [ISO]
- microglial cell proliferation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of protein homooligomerization [ISO]
- neuron projection morphogenesis [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of tau-protein kinase activity [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- protein import [ISO]
- protein stabilization [ISO]
- regulation of beta-amyloid clearance [ISO]
- regulation of neuron death [ISO]
- regulation of neuronal signal transduction [ISO]
- response to misfolded protein [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- aggresome [ISO]
- apical dendrite [ISO]
- blood microparticle [ISO]
- cytoplasm [ISO]
- extracellular matrix [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- growth cone [ISO]
- mitochondrion [ISO]
- neurofibrillary tangle [ISO]
- neuron projection [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- spherical high-density lipoprotein particle [ISO]
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.817 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PRNP CLU | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID