BAIT
PIK3R1
PI3K, p50alpha, p55alpha, p85alpha
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
GO Process (39)
GO Function (23)
GO Component (11)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- NFAT protein import into nucleus [IMP]
- cellular glucose homeostasis [IDA]
- cellular response to UV [IGI, IMP]
- cellular response to insulin stimulus [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI, IMP]
- glucose metabolic process [ISO]
- growth hormone receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, IMP]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of blood pressure [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cell-matrix adhesion [IGI]
- negative regulation of heart rate [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of osteoclast differentiation [IGI]
- negative regulation of proteolysis [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- phosphatidylinositol phosphorylation [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [ISO, TAS]
- positive regulation of RNA splicing [ISO]
- positive regulation of cell migration [IGI, ISO]
- positive regulation of endoplasmic reticulum unfolded protein response [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of myoblast differentiation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription factor import into nucleus [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of tumor necrosis factor production [IMP]
- protein phosphorylation [IDA]
- protein stabilization [ISO]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
- response to cAMP [ISO]
- response to endoplasmic reticulum stress [IDA, ISO]
- response to glucocorticoid [ISO]
- response to insulin [ISO]
Gene Ontology Molecular Function- 1-phosphatidylinositol-3-kinase activity [ISO, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [ISO]
- ATPase binding [ISO]
- ErbB-3 class receptor binding [ISO]
- calmodulin binding [ISO]
- estrogen receptor binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- 1-phosphatidylinositol-3-kinase activity [ISO, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [ISO]
- ATPase binding [ISO]
- ErbB-3 class receptor binding [ISO]
- calmodulin binding [ISO]
- estrogen receptor binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
CTNNB1
Bfc, Catnb, Mesc
catenin (cadherin associated protein), beta 1
GO Process (137)
GO Function (14)
GO Component (29)
Gene Ontology Biological Process
- T cell differentiation [IMP]
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA]
- adherens junction organization [IMP]
- anterior/posterior axis specification [IMP]
- bone resorption [IGI, IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [IMP]
- cardiac muscle cell proliferation [TAS]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell differentiation [IMP]
- cell fate determination [IMP]
- cell fate specification [IMP]
- cell maturation [IDA, IMP]
- cell morphogenesis involved in differentiation [IMP]
- cell proliferation [IMP]
- cell-matrix adhesion [IMP]
- cellular process [IDA]
- cellular protein localization [IMP]
- cellular response to organic cyclic compound [IDA]
- central nervous system vasculogenesis [IMP]
- chromatin-mediated maintenance of transcription [IMP]
- coronary artery morphogenesis [TAS]
- dorsal/ventral axis specification [IMP]
- dorsal/ventral pattern formation [IMP]
- ectoderm development [IMP]
- embryonic axis specification [IDA]
- embryonic digit morphogenesis [IGI, IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic forelimb morphogenesis [IDA]
- embryonic heart tube development [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic skeletal limb joint morphogenesis [IGI]
- endoderm formation [IMP]
- endodermal cell fate commitment [IMP]
- epicardium-derived cardiac vascular smooth muscle cell differentiation [TAS]
- epithelial cell differentiation involved in prostate gland development [IMP]
- epithelial tube branching involved in lung morphogenesis [IMP]
- forebrain development [IMP]
- fungiform papilla formation [IMP]
- gastrulation with mouth forming second [IMP]
- genitalia morphogenesis [IMP]
- glial cell fate determination [IDA]
- hair cycle process [IMP]
- hair follicle morphogenesis [IMP]
- hair follicle placode formation [IGI, IMP]
- heart development [IMP]
- hemopoiesis [IDA]
- in utero embryonic development [IGI, IMP]
- kidney development [IMP]
- layer formation in cerebral cortex [IMP]
- lens morphogenesis in camera-type eye [IMP]
- limb development [IMP]
- lung cell differentiation [IMP]
- lung development [IMP]
- lung induction [IMP]
- lung-associated mesenchyme development [IMP]
- male genitalia development [IMP]
- mesenchymal cell proliferation involved in lung development [IMP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- mesenchyme development [TAS]
- mesenchyme morphogenesis [TAS]
- metanephros morphogenesis [IMP]
- morphogenesis of embryonic epithelium [IMP]
- negative regulation of apoptotic signaling pathway [IGI, IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of chondrocyte differentiation [IGI]
- negative regulation of mitotic cell cycle, embryonic [IMP]
- negative regulation of neuron death [IGI]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoclast differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- nephron tubule formation [IMP]
- neural plate development [IDA]
- neuron migration [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- oocyte development [IGI]
- organ development [IMP]
- osteoclast differentiation [IMP]
- oviduct development [IMP]
- pancreas development [IMP]
- patterning of blood vessels [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IGI]
- positive regulation of branching involved in lung morphogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of determination of dorsal identity [IDA]
- positive regulation of endothelial cell differentiation [IMP]
- positive regulation of epithelial cell differentiation [IMP]
- positive regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of epithelial to mesenchymal transition [ISO, TAS]
- positive regulation of fibroblast growth factor receptor signaling pathway [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuroblast proliferation [IGI, IMP]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of telomerase activity [IMP]
- positive regulation of telomere maintenance via telomerase [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- proximal/distal pattern formation [IMP]
- regulation of T cell proliferation [IMP]
- regulation of apoptotic process [IMP]
- regulation of cell differentiation [IDA]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [IDA, IMP]
- regulation of centromeric sister chromatid cohesion [IMP]
- regulation of epithelial cell differentiation [IMP]
- regulation of gene expression [IMP]
- regulation of myelination [IMP]
- regulation of nephron tubule epithelial cell differentiation [IMP]
- regulation of osteoblast differentiation [IMP]
- regulation of osteoclast differentiation [IMP]
- regulation of secondary heart field cardioblast proliferation [IDA]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- renal inner medulla development [IMP]
- renal outer medulla development [IMP]
- renal system development [IMP]
- renal vesicle formation [IMP]
- single organismal cell-cell adhesion [IMP]
- skeletal system development [IMP]
- skin development [IMP]
- smooth muscle cell differentiation [IMP]
- stem cell maintenance [TAS]
- sympathetic ganglion development [IMP]
- synapse organization [IMP]
- synaptic transmission [IMP]
- synaptic vesicle transport [IMP]
- thymus development [IMP]
- trachea formation [IMP]
- trachea morphogenesis [IMP]
- vasculature development [IMP]
- vasculogenesis [IMP]
- ventricular compact myocardium morphogenesis [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- alpha-catenin binding [IDA, IPI]
- cadherin binding [IPI, ISO]
- chromatin binding [IDA, IGI]
- double-stranded DNA binding [IDA]
- euchromatin binding [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- alpha-catenin binding [IDA, IPI]
- cadherin binding [IPI, ISO]
- chromatin binding [IDA, IGI]
- double-stranded DNA binding [IDA]
- euchromatin binding [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [IDA]
- Z disc [IDA]
- adherens junction [IDA]
- apical junction complex [IDA]
- apical part of cell [IDA]
- basolateral plasma membrane [IDA]
- beta-catenin destruction complex [IDA]
- catenin complex [IBA]
- catenin-TCF7L2 complex [IDA]
- cell [IMP]
- cell projection membrane [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA, ISO]
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- fascia adherens [IDA]
- intercalated disc [IDA]
- lamellipodium [IDA]
- lateral plasma membrane [IDA, ISO]
- membrane [IDA]
- microvillus membrane [IDA]
- nuclear euchromatin [IDA]
- nuclear transcription factor complex [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- protein complex [ISO]
- tight junction [IDA]
- transcription factor complex [IDA]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.8215 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID