BAIT
PKM
AA414905, AL024370, AL024424, Pk-2, Pk-3, Pk3, Pkm2
pyruvate kinase, muscle
GO Process (9)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DAPK1
D13Ucla1, DAP-Kinase
death associated protein kinase 1
GO Process (12)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- apoptotic process [ISO]
- apoptotic signaling pathway [ISO, TAS]
- cellular response to interferon-gamma [IMP, ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI, IMP]
- intracellular signal transduction [IDA, ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of translation [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, IDA, ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7845 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID