BAIT
PDCD6
AV299538, Alg2, MA-3, PS2, alg-2
programmed cell death 6
GO Process (14)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic process [IDA]
- cellular response to heat [ISO]
- intracellular protein transport [ISO]
- negative regulation of TOR signaling [ISO]
- negative regulation of protein kinase B signaling [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- proteolysis [IBA]
- response to calcium ion [IDA]
- vascular endothelial growth factor receptor-2 signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DDX1
AA409185, DBP-RB
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
GO Process (8)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA duplex unwinding [ISO]
- double-strand break repair [ISO]
- nucleic acid phosphodiester bond hydrolysis [ISO]
- regulation of nucleic acid-templated transcription [ISO]
- response to exogenous dsRNA [IMP]
- response to virus [IMP]
- tRNA splicing, via endonucleolytic cleavage and ligation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.719 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID