BAIT
PRKACA
PKCD, Pkaca
protein kinase, cAMP dependent, catalytic, alpha
GO Process (20)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- cellular response to parathyroid hormone stimulus [IMP]
- mesoderm formation [IGI]
- negative regulation of meiotic cell cycle [ISO]
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IGI]
- neural tube closure [IGI]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of protein export from nucleus [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISO]
- regulation of cellular respiration [ISO]
- regulation of osteoblast differentiation [ISO]
- regulation of proteasomal protein catabolic process [ISO]
- regulation of protein processing [IGI]
- regulation of synaptic transmission [IMP]
- regulation of synaptic transmission, glutamatergic [ISO]
- regulation of tight junction assembly [ISO]
- sperm capacitation [IDA]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- cAMP-dependent protein kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA]
- protein serine/threonine/tyrosine kinase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- Rab GTPase binding [ISO]
- cAMP-dependent protein kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA]
- protein serine/threonine/tyrosine kinase activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- AMP-activated protein kinase complex [ISO]
- Golgi apparatus [ISO]
- cAMP-dependent protein kinase complex [ISO]
- centrosome [ISO]
- ciliary base [IDA]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- mitochondrion [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sperm midpiece [ISO]
Mus musculus
PREY
DMTN
AI325486, Epb4.9, Epb49, dematin
dematin actin binding protein
GO Process (27)
GO Function (4)
GO Component (13)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- actin filament bundle assembly [ISO]
- actin filament reorganization [IMP]
- calcium-mediated signaling using extracellular calcium source [IMP]
- calcium-mediated signaling using intracellular calcium source [IMP]
- cellular response to cAMP [ISO]
- cellular response to calcium ion [IMP]
- erythrocyte development [IMP]
- negative regulation of cell-substrate adhesion [IMP]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- negative regulation of peptidyl-threonine phosphorylation [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP]
- negative regulation of protein targeting to membrane [IMP]
- negative regulation of substrate adhesion-dependent cell spreading [IMP]
- positive regulation of blood coagulation [IMP]
- positive regulation of fibroblast migration [IDA]
- positive regulation of integrin-mediated signaling pathway [IMP]
- positive regulation of platelet aggregation [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- positive regulation of wound healing [IMP]
- protein complex assembly [IDA, ISO]
- protein secretion by platelet [IMP]
- regulation of actin cytoskeleton organization [ISO]
- regulation of cell shape [IDA, IMP, ISO]
- regulation of filopodium assembly [ISO]
- regulation of lamellipodium assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin filament [ISO]
- cell [IMP]
- cell projection membrane [IDA]
- cortical cytoskeleton [IDA]
- cytoplasmic membrane-bounded vesicle [ISO]
- cytosol [IDA, ISO]
- intracellular [IMP]
- membrane [IDA]
- neuronal postsynaptic density [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO]
- platelet dense tubular network membrane [ISO]
- spectrin-associated cytoskeleton [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7405 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID