BAIT
ASAP1
AV239055, DEF-1, Ddef1, PAP, mKIAA1249, s19
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
GO Process (2)
GO Function (4)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
GAB1
AA408973, AW107238
growth factor receptor bound protein 2-associated protein 1
GO Process (12)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- activation of JUN kinase activity [IMP]
- activation of MAPK activity [IDA]
- epidermal growth factor receptor signaling pathway [IMP]
- epidermis development [IMP]
- heart development [IMP]
- interleukin-6-mediated signaling pathway [IMP]
- labyrinthine layer development [IMP]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive regulation of MAPK cascade [IMP]
- regulation of cell migration [IGI]
- response to oxidative stress [IDA]
- signal transduction [IDA]
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.782 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID