BAIT
GNAO1
AW050213, Galphao, Gnao, alphaO
guanine nucleotide binding protein, alpha O
GO Process (11)
GO Function (10)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO, TAS]
- GTP catabolic process [ISO]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- aging [ISO]
- cellular process [IMP]
- dopamine receptor signaling pathway [IMP]
- locomotory behavior [IMP]
- negative regulation of calcium ion transport [ISO]
- positive regulation of GTPase activity [ISO]
- regulation of heart contraction [IMP]
- response to organonitrogen compound [ISO]
Gene Ontology Molecular Function- G-protein beta/gamma-subunit complex binding [IBA]
- G-protein coupled serotonin receptor binding [IBA, ISO]
- GTP binding [IMP, ISO]
- GTPase activating protein binding [ISO]
- GTPase activity [IDA, ISO, TAS]
- corticotropin-releasing hormone receptor 1 binding [IBA, ISO]
- mu-type opioid receptor binding [IBA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- signal transducer activity [IBA]
- G-protein beta/gamma-subunit complex binding [IBA]
- G-protein coupled serotonin receptor binding [IBA, ISO]
- GTP binding [IMP, ISO]
- GTPase activating protein binding [ISO]
- GTPase activity [IDA, ISO, TAS]
- corticotropin-releasing hormone receptor 1 binding [IBA, ISO]
- mu-type opioid receptor binding [IBA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- signal transducer activity [IBA]
Gene Ontology Cellular Component
Mus musculus
PREY
GNAQ
1110005L02Rik, 6230401I02Rik, AA408290, AW060788, Dsk1, Dsk10, Galphaq, Gq, GqI
guanine nucleotide binding protein, alpha q polypeptide
GO Process (25)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO]
- GTP catabolic process [IBA]
- action potential [IMP]
- activation of phospholipase C activity [ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA]
- developmental pigmentation [IMP]
- embryonic digit morphogenesis [IGI]
- forebrain neuron development [IMP]
- glutamate receptor signaling pathway [IMP]
- heart development [IMP]
- maternal behavior [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of potassium ion transport [ISO]
- negative regulation of protein kinase activity [ISO]
- neuron remodeling [IMP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISO]
- phospholipase C-activating dopamine receptor signaling pathway [IGI]
- positive regulation of GTPase activity [IBA, ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- post-embryonic development [IMP]
- protein stabilization [ISO]
- regulation of catenin import into nucleus [ISO]
- regulation of melanocyte differentiation [IMP]
- signal transduction [IBA]
- skeletal system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.851 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID