HSPD1
Gene Ontology Biological Process
- B cell activation [ISO]
- B cell cytokine production [ISO]
- B cell proliferation [ISO]
- MyD88-dependent toll-like receptor signaling pathway [ISO]
- T cell activation [IDA, IGI, ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- chaperone mediated protein folding requiring cofactor [ISO]
- detection of misfolded protein [ISO]
- isotype switching to IgG isotypes [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of T cell activation [IDA, ISO]
- positive regulation of T cell mediated immune response to tumor cell [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-alpha production [IDA, ISO]
- positive regulation of interferon-gamma production [IDA, IGI, ISO]
- positive regulation of interleukin-10 production [ISO]
- positive regulation of interleukin-12 production [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of macrophage activation [ISO]
- protein refolding [ISO]
- protein stabilization [ISO]
- response to unfolded protein [ISO]
Gene Ontology Molecular Function- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [ISO]
- lipopolysaccharide binding [IDA, ISO]
- misfolded protein binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [ISO]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [ISO]
- lipopolysaccharide binding [IDA, ISO]
- misfolded protein binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [ISO]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell surface [ISO]
- coated pit [ISO]
- coated vesicle [ISO]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [IDA]
- lipopolysaccharide receptor complex [ISO]
- membrane [ISO]
- membrane raft [ISO]
- mitochondrial crista [ISO]
- mitochondrial inner membrane [IDA]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- plasma membrane [IDA]
- protein complex [ISO]
- rough endoplasmic reticulum [ISO]
- secretory granule [IDA, ISO]
- zymogen granule [ISO]
HSPE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.878 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HSPE1 HSPD1 | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | 3735528 | |
| HSPD1 HSPE1 | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | 3735529 |
Curated By
- BioGRID