BAIT
PEA15A
Mat1, PEA-15, Pea15, Pkcs15
phosphoprotein enriched in astrocytes 15A
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HTRA2
AI481710, Omi, Prss25, mnd2
HtrA serine peptidase 2
GO Process (20)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- adult walking behavior [IMP]
- cellular protein catabolic process [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to heat [ISO]
- cellular response to interferon-beta [ISO]
- cellular response to retinoic acid [ISO]
- forebrain development [IMP]
- intrinsic apoptotic signaling pathway [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- mitochondrion organization [IMP]
- negative regulation of cell death [ISO]
- neuron development [IMP]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of cell death [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- proteolysis [ISO]
- regulation of multicellular organism growth [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.787 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID