CASK
Gene Ontology Biological Process
- calcium ion import [IMP]
- intracellular protein transport [ISO]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of cellular response to growth factor stimulus [ISO]
- negative regulation of keratinocyte proliferation [ISO]
- negative regulation of wound healing [ISO]
- positive regulation of calcium ion import [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basement membrane [IDA, ISO]
- basolateral plasma membrane [IDA]
- cell-cell junction [IDA, ISO]
- ciliary membrane [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- dendrite [ISO]
- focal adhesion [ISO]
- membrane [IDA, ISO]
- nuclear lamina [ISO]
- nuclear matrix [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- presynaptic membrane [ISO]
- protein complex [ISO]
- synapse [IDA]
- synaptic membrane [ISO]
LIN7C
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.947 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
LIN7C CASK | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
LIN7C CASK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1416143 | |
LIN7C CASK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
CASK LIN7C | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 1416144 | |
LIN7C CASK | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 1416145 |
Curated By
- BioGRID